Depline Plus 12.5 mg/5 mg Tablet

Depline Plus 12.5 mg/5 mg Tablet is a combination of two medicines. It is used in the treatment of depression associated with anxiety. It helps in regulating mood and to reduce anxiety.

Depline Plus 12.5 mg/5 mg Tablet is taken with or without food. However, it is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. In case you miss a dose of this medicine, take it as soon as you remember. Never skip any dose and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to the doctor as it may worsen your symptoms. Taking this medicine for a long time may require regular monitoring of blood and liver functions.

Some common side effects of this medicine include constipation, difficulty in urination, weight gain, confusion, orthostatic hypotension (sudden lowering of blood pressure on standing). This medicine may cause weight loss. In case of losing weight, consult a dietitian for dietary supplements or try to increase your food portion. Most of the common side effects tend to be mild. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects are rare. Remember to inform your doctor if you develop any unusual changes in mood as it may lead to suicidal thoughts.

Take caution while taking medicine if you are suffering from liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

• Treatment of Depression

Treatment of Depression
Depline Plus 12.5 mg/5 mg Tablet works by affecting the balance of certain chemicals (such as serotonin) in the brain. It helps improve mood and feelings of wellbeing, relieve anxiety and tension, helps you sleep better, and increase your energy level. It is an effective antidepressant but may cause drowsiness. You need to take it regularly as it is prescribed for it to be most effective and should not stop taking it suddenly.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Amipox

• Constipation
• Difficulty in urination
• Weight gain
• Confusion
• Orthostatic hypotension (sudden lowering of blood pressure on standing)
• Tiredness
• Blurred vision
• Dryness in mouth
• Increased heart rate
• Uncoordinated body movements
• Depression
• Memory impairment

Take this medicine in the dose and duration as advised by your doctor. Depline Plus 12.5 mg/5 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

Depline Plus 12.5 mg/5 mg Tablet is a combination of two medicines: Amitriptyline and Chlordiazepoxide, which treats depression. Amitriptyline is a tricyclic antidepressant which increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression. Chlordiazepoxide is a benzodiazepine (BZD) which works by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in the brain.

• Depline Plus 12.5 mg/5 mg Tablet is prescribed for the treatment of depression.
• It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or two, feeling it is not helping.
• Do not stop taking Depline Plus 12.5 mg/5 mg Tablet unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
• Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
• Inform your doctor if you are taking any other antidepressants.
• Inform your doctor immediately if you get thoughts about harming yourself or ending your life.
• Avoid alcohol while taking Depline Plus 12.5 mg/5 mg Tablet.
• If you have diabetes, you will be asked to monitor your blood glucose level regularly as Depline Plus 12.5 mg/5 mg Tablet may affect the levels of sugar in your blood.
• Depline Plus 12.5 mg/5 mg Tablet is prescribed for the treatment of depression.
• It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or two, feeling it is not helping.
• Do not stop taking Depline Plus 12.5 mg/5 mg Tablet unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
• Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
• Inform your doctor if you are taking any other antidepressants.
• Inform your doctor immediately if you get thoughts about harming yourself or ending your life.
• Avoid alcohol while taking Depline Plus 12.5 mg/5 mg Tablet.
• If you have diabetes, you will be asked to monitor your blood glucose level regularly as Depline Plus 12.5 mg/5 mg Tablet may affect the levels of sugar in your blood.

DailyMed. Chlordiazepoxide and amitriptyline hydrochloride. [Accessed 10 Apr. 2019] (online) Available from:

Amitriptyline. North Harrow, Middlesex: Accord Healthcare Limited; 2018. [Accessed 10 Apr. 2019] (online) Available from:

MedlinePlus. Chlordiazepoxide. [Accessed 10 Apr. 2019] (online) Available from: