Amitriptyline + Chlordiazepoxide

Introduction To Amitriptyline + Chlordiazepoxide

Amitriptyline + Chlordiazepoxide is a combination of two medicines. It is used in the treatment of depression associated with anxiety. It helps in regulating mood and to reduce anxiety.

Amitriptyline + Chlordiazepoxide is taken with or without food. However, it is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. In case you miss a dose of this medicine, take it as soon as you remember. Never skip any dose and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to the doctor as it may worsen your symptoms. Taking this medicine for a long time may require regular monitoring of blood and liver functions.

Some common side effects of this medicine include constipation, difficulty in urination, weight gain, confusion, orthostatic hypotension (sudden lowering of blood pressure on standing). This medicine may cause weight loss. In case of losing weight, consult a dietitian for dietary supplements or try to increase your food portion. Most of the common side effects tend to be mild. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects are rare. Remember to inform your doctor if you develop any unusual changes in mood as it may lead to suicidal thoughts.

Take caution while taking medicine if you are suffering from liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Uses of Amitriptyline + Chlordiazepoxide

  • Treatment of Depression

Benefits of Amitriptyline + Chlordiazepoxide

Treatment of Depression
Amitriptyline + Chlordiazepoxide works by affecting the balance of certain chemicals (such as serotonin) in the brain. It helps improve mood and feelings of wellbeing, relieve anxiety and tension, helps you sleep better, and increase your energy level. It is an effective antidepressant but may cause drowsiness. You need to take it regularly as it is prescribed for it to be most effective and should not stop taking it suddenly.

Side effects of Amitriptyline + Chlordiazepoxide

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Amipox

  • Constipation
  • Difficulty in urination
  • Weight gain
  • Confusion
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Tiredness
  • Blurred vision
  • Dryness in mouth
  • Increased heart rate
  • Uncoordinated body movements
  • Depression
  • Memory impairment

How to use Amitriptyline + Chlordiazepoxide

Take this medicine in the dose and duration as advised by your doctor. Amitriptyline + Chlordiazepoxide may be taken with or without food, but it is better to take it at a fixed time.

How Amitriptyline + Chlordiazepoxide works

Amitriptyline + Chlordiazepoxide is a combination of two medicines: Amitriptyline and Chlordiazepoxide, which treats depression. Amitriptyline is a tricyclic antidepressant which increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression. Chlordiazepoxide is a benzodiazepine (BZD) which works by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in the brain.

Quick tips

  • Amitriptyline + Chlordiazepoxide is prescribed for the treatment of depression.
  • It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or two, feeling it is not helping.
  • Do not stop taking Amitriptyline + Chlordiazepoxide unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
  • Inform your doctor if you are taking any other antidepressants.
  • Inform your doctor immediately if you get thoughts about harming yourself or ending your life.
  • Avoid alcohol while taking Amitriptyline + Chlordiazepoxide.
  • If you have diabetes, you will be asked to monitor your blood glucose level regularly as Amitriptyline + Chlordiazepoxide may affect the levels of sugar in your blood.
  • Amitriptyline + Chlordiazepoxide is prescribed for the treatment of depression.
  • It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or two, feeling it is not helping.
  • Do not stop taking Amitriptyline + Chlordiazepoxide unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
  • Inform your doctor if you are taking any other antidepressants.
  • Inform your doctor immediately if you get thoughts about harming yourself or ending your life.
  • Avoid alcohol while taking Amitriptyline + Chlordiazepoxide.
  • If you have diabetes, you will be asked to monitor your blood glucose level regularly as Amitriptyline + Chlordiazepoxide may affect the levels of sugar in your blood.

Safety Advice

sdsPregnancyCONSULT YOUR DOCTOR

Can I take Amitriptyline + Chlordiazepoxide if I’m pregnant?

Amitriptyline + Chlordiazepoxide is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

sdsBreastfeedingCONSULT YOUR DOCTOR

Can I take Amitriptyline + Chlordiazepoxide if I’m breastfeeding?

Amitriptyline + Chlordiazepoxide is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

sdsAlcoholUNSAFE

Is drinking alcohol while taking Amitriptyline + Chlordiazepoxide safe?

It is unsafe to consume alcohol with Amitriptyline + Chlordiazepoxide.

sdsDrivingUNSAFE

Can I drive after taking Amitriptyline + Chlordiazepoxide?

Amitriptyline + Chlordiazepoxide may cause side effects which could affect your ability to drive. As Amitriptyline + Chlordiazepoxide may make you feel drowsy or affect your concentration and this may affect your ability to drive.

sdsKidneySAFE IF PRESCRIBED

Can I take Amitriptyline + Chlordiazepoxide if I have/had kidney diseases?

Amitriptyline + Chlordiazepoxide is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Amitriptyline + Chlordiazepoxide may not be needed in these patients. Please consult your doctor.

sdsLiverCAUTION

Can I take Amitriptyline + Chlordiazepoxide if I have/had liver diseases?

Amitriptyline + Chlordiazepoxide should be used with caution in patients with liver disease. Dose adjustment of Amitriptyline + Chlordiazepoxide may be needed. Please consult your doctor.

Frequently Asked Questions

Q. Are there any important warnings associated with use of Amitriptyline + Chlordiazepoxide?

During the first few months of treatment, Amitriptyline + Chlordiazepoxide may increase suicidal thoughts or actions in some patients. Patients having mood or behavioral disorder have a high risk of developing suicidal thoughts and actions. You should pay close attention and report your doctor of any such behavior or mood changes. Make sure that you visit the doctor for the scheduled follow-up appointments.

Q. Can I stop taking Amitriptyline + Chlordiazepoxide when my symptoms are relieved?

No, you should continue to take Amitriptyline + Chlordiazepoxide, even if you feel well. If you stop Amitriptyline + Chlordiazepoxide suddenly, serious withdrawal symptoms may occur. Consult your doctor if the symptoms are relieved, he might decrease your dose gradually.

Q. How to manage weight gain associated with the use of Amitriptyline + Chlordiazepoxide?

There are reports which suggest that the use of Amitriptyline + Chlordiazepoxide can cause weight gain. If you maintain good eating habits and exercise regularly, you might not gain any weight. An important to remember is that it is easier to prevent weight gain than losing increased weight.

Q. What are the instructions for storage and disposal of Amitriptyline + Chlordiazepoxide?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. Can the use of Amitriptyline + Chlordiazepoxide cause sleepiness?

Yes, Amitriptyline + Chlordiazepoxide can make you feel sleepy. Avoid driving, operating machinery, working at heights or participating in potentially dangerous activities till you know how this medicine affects you.

Q. Can the use of Amitriptyline + Chlordiazepoxide affect my sexual life?

The use of Amitriptyline + Chlordiazepoxide can affect the sexual life of both men and women. Most commonly caused problems are decreased sexual desire, erectile dysfunction (inability to develop or maintain erection during the sexual activity) and inability to reach orgasm. It can also cause a decrease in satisfaction and cause discomfort while having sex. If you experience these problems, discuss with your doctor.

Q. Can I drink alcohol while taking Amitriptyline + Chlordiazepoxide?

No, do not drink alcohol while you are taking Amitriptyline + Chlordiazepoxide. Drinking alcohol can increase the severity of drowsiness or sleepiness caused by Amitriptyline + Chlordiazepoxide.

Q. Can the use of Amitriptyline + Chlordiazepoxide change the color of urine?

Yes, Amitriptyline + Chlordiazepoxide can the change the color of the urine to blue or green. This change of color is expected while using Amitriptyline + Chlordiazepoxide, and it is not harmful. Your urine color becomes normal once you stop taking Amitriptyline + Chlordiazepoxide.

Q. How long does Amitriptyline + Chlordiazepoxide take to work?

Everybody responds differently to the treatment. In general, it can take several weeks to feel the full benefits of Amitriptyline + Chlordiazepoxide, although some people will start to feel better sooner. When taking Amitriptyline + Chlordiazepoxide, it is important to give it time to work.

References

Written By:

Dr Advikka Ridhy

Dr Advikka Ridhy

MBBS

RMO, Aster MIMS

Disclaimer: The contents of this material are solely intended for informational purposes and do not serve as a substitute for professional medical advice, diagnosis, or treatment. MediClap does not offer advice, endorse any specific prescription drug, pharmacy, or other information on the site. Furthermore, MediClap does not provide any warranty for the information presented. It is recommended that you seek medical advice prior to commencing, altering, or terminating any medical treatment.
MediClap strives to make its website accessible to all users, including those with disabilities. Should you encounter any difficulty accessing this website, kindly send an email to hello@mediclap.com to enable us to provide the necessary services through alternative means.
MediClap is not affiliated with nor sponsored by any of the third-party brands mentioned. All trademarks, brands, logos, and copyrights mentioned remain the sole property of their respective owners.