Ryzodeg 100IU/ml Penfill

Ryzodeg 100IU/ml Penfill is a combination of two medicines, a long-acting and a rapid-acting type of insulin used to treat types 1 and 2 diabetes mellitus in both adults and children. It provides a steady level of insulin in the body for an entire day and helps control blood sugar levels.

Ryzodeg 100IU/ml Penfill can be prescribed by itself or along with other diabetes medicines. Your doctor or nurse will teach you the correct way of injecting it under the skin. You should use this medicine regularly as per the dose advised to get the most benefit. It is usually taken once daily at the same time every day. However, on occasions when administration at the same time of the day is not possible, it may be taken at a different time of the day. Always ensure that there is a minimum gap of 8 hours between doses.

If you stop taking it your blood sugar levels may rise very high and put you at risk of serious complications. It is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor.

The most common side effect of this medicine is low blood sugar levels (hypoglycemia). To prevent this, it is important to always inject the correct dose of medicine only, have regular meals, and monitor your blood sugar levels regularly. Drinking excessive alcohol can also lead to a fall in your blood sugar levels. Other side effects include allergy at the injection site like redness, swelling, or hard lumps (lipohypertrophy). Some people gain weight while taking insulin. You may also notice a rash, edema (swelling), or itching while taking this medicine.

Do not use this medicine when you have low blood sugar levels (hypoglycemia). Tell your doctor if you have ever had kidney, liver or heart problems before starting treatment. Pregnant or breastfeeding women should also consult their doctor before using it.

• Diabetes

Diabetes
Ryzodeg 100IU/ml Penfill contains Insulin degludec, that has a prolonged duration of action as well as insulin aspart, that has a fast onset of action. Together, they ensure rapid and consistent sugar control that helps control blood sugar levels for an entire day. It is given as an injection and your doctor or nurse will train you on the correct way to inject it. Managing blood glucose levels is an essential part of managing diabetes. If you can control the level you will reduce the risk of getting any of the serious complications of diabetes such as kidney damage, eye damage, nerve problems, and loss of limbs. Taking this medicine regularly along with proper diet and exercise will help you live a normal, healthy life.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Ryzodeg

• Hypoglycemia (low blood glucose level)
• Auto-antibody formation
• Headache
• Nasopharyngitis (inflammation of the throat and nasal passages)
• Upper respiratory tract infection

Your doctor or nurse will guide you how to use this medicine.

Ryzodeg 100IU/ml Penfill is a combination of two insulin preparations: Insulin degludec and insulin aspart. Insulin degludec has a prolonged duration of action while insulin aspart has a fast onset of action. Together, they ensure rapid and consistent sugar control by facilitating reuptake of sugar in muscle and fat cells, and suppressing the production of sugar in the liver.

• Take it 15 minutes before a meal or within 20 minutes after starting a meal.
• Injection below the skin of the abdomen results in faster absorption as compared to other injection sites such as skin of the upper arms, thighs, or buttocks. After injection, the site of injection should not be massaged.
• Injection sites must be rotated to prevent hard lumps from developing at one site.
• Change to another type or brand of insulin should be done under strict medical supervision as it may require a change in dosage.
• Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.
• Do not share your insulin device with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.
• Opened vials / cartridge are good at room temperature for up to 4 weeks, while unopened vials must be placed in the refrigerator (2°C–8°C).

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Insulin Degludec. Gatwick, West Sussex: Novo Nordisk Limited; 2013 [revised Nov. 2018]. [Accessed 08 Apr. 2019] (online) Available from:

Ryzodeg [Summary of Product Characteristics]. Novo Allé, Denmark; Novo Nordisk A/S; 2021. [Accessed 12 Oct. 2021] (online) Available from:

Ryzodeg [FDA Prescribing Information]. Bagsvaerd, Denmark; Novo Nordisk A/S; 2019. [Accessed 12 Oct. 2021] (online) Available from: