PD Nor TZ 400 mg/600 mg Tablet

PD Nor TZ 400 mg/600 mg Tablet is a prescription medicine used to treat stomach and intestinal infections that cause diarrhoea. It consists of two antimicrobial drugs: norfloxacin and tinidazole, which work together to treat diarrhoea, vomiting, and painful stomach cramps. This medication is usually prescribed for dysentery, amebiasis, giardiasis and other microbial infections.

PD Nor TZ 400 mg/600 mg Tablet should be taken as advised by your doctor. It is best to take them whole after your meal with plenty of fluids to avoid stomach discomfort. To prevent adverse effects, take it as per your doctor’s prescription. Do not discontinue taking this medicine even if you feel better.

The common side effects of PD Nor TZ 400 mg/600 mg Tablet include nausea, tiredness, dry mouth with a metallic taste and headache. They typically last for a short period and should not be of any concern.

PD Nor TZ 400 mg/600 mg Tablet is contraindicated for people with a history of liver diseases, renal failure, nerve disorders, and allergies to either norfloxacin or tinidazole. Always let your doctor know of any health conditions you might have. Generally, this combination drug is considered safe for most people.

PD Nor TZ 400 mg/600 mg Tablet is a combination medicine used in the treatment of diarrhoea caused by stomach and intestinal infections. It helps reduce the main symptoms of gastric infections, such as stomach pain, diarrhoea (loose stools, bloody stools), vomiting, and painful stomach cramps. This medication is usually prescribed for dysentery, amebiasis, giardiasis and other microbial infections such as Trichomoniasis.

This medication consists of 2 active ingredients: norfloxacin and tinidazole. They act as antimicrobial drugs and kill/halt the growth of infective agents such as protozoa, parasites and anaerobic bacteria.

PD Nor TZ 400 mg/600 mg Tablet is prescribed to patients with severe diarrhoea due to an infection either in the stomach or colon. It quickly enters the body and removes the microbes causing the infection and diarrhoea. The excess water loss is mitigated by giving fluids to the person until the risk of dehydration is avoided.

PD Nor TZ 400 mg/600 mg Tablet is a combination of two antimicrobial drugs: an antibiotic and an antiprotozoal. Both, when administered together, kill the harmful bacteria and protozoan parasites that cause the infection in the gastrointestinal tract.

PD Nor TZ 400 mg/600 mg Tablet includes two active ingredients: norfloxacin and tinidazole. Let’s look at what they do individually to understand how they work when combined.

Norfloxacin, simply put, is an antibiotic. It comes under the class of antibiotic drugs called fluoroquinolones. They work as broad-spectrum drugs (which means they are functional against a wide range of bacteria) and are used to kill both gram-positive and gram-negative bacteria.

The way norfloxacin works is by preventing the bacterial cells from multiplying. It functions by blocking/inhibiting certain enzymes within the cell, such as DNA gyrase, type II topoisomerase, and topoisomerase IV enzymes. These enzymes are necessary for the separation of bacterial DNA, which is crucial for cell division.

Tinidazole is a nitroimidazole antimicrobial. It works against both parasites (protozoans) and anaerobic bacteria. The mechanism of action involves the activation of this drug by the enzymes the microbes produce; upon activation, certain toxic compounds are formed, which are harmful to the cells of these microbes. This results in the damage of proteins, membranes and the DNA found inside the cell.

Tinidazole is used to treat trichomoniasis (an STD caused by Trichomonas vaginalis), giardiasis (a diarrheal disease caused by Giardia duodenalis), and amebiasis (an intestinal infection caused by Entamoeba histolytica) - all protozoal infections.

• Tinidazole (ncbi.nlm.nih.gov)
• Norfloxacin: a brief overview (pubchem.ncbi.nlm.nih.gov)
• Oral Antiprotozoal Drugs (drugoffice.gov.hk)