Nuclona-Plus Tablet

Nuclona-Plus Tablet is a combination medicine used to treat anxiety. It contains two ingredients: clonazepam, an anxiolytic and escitalopram, an antidepressant. Both work together on the central nervous system to improve moods, calm the brain, and relieve signs of anxiety such as nervousness, rapid breathing and trembling.

Nuclona-Plus Tablet should be taken as advised by your doctor. It contains clonazepam, which is a highly addictive anxiety medication so take it with precautions. Do not take more than the prescribed dose. To prevent withdrawal symptoms, avoid suddenly stopping the use of the medicine.

Side effects of Nuclona-Plus Tablet include behaviour disturbances, confusion, memory problems, uncoordinated body movements, drowsiness, delayed ejaculation and low sex drive. Contact your doctor if these side effects are significantly affecting your daily life.

Nuclona-Plus Tablet is contraindicated for people with severe liver disease or hypersensitivity to either clonazepam or escitalopram. Always let your doctor know of any health conditions you might have. Generally, this combination drug is considered safe for most people.

Nuclona-Plus Tablet is a combination medicine containing escitalopram and clonazepam, and it is used for patients with anxiety disorder. Escitalopram is an antidepressant and clonazepam is an anticonvulsant and an anxiolytic. They work together by controlling abnormal brain activity and improving mood by increasing a particular neurotransmitter.

Nuclona-Plus Tablet helps people with clinical anxiety by alleviating symptoms like a constant and exaggerated sense of tension, twitching, poor concentration, headache, nausea and irritability. The medicine enables people with an anxiety disorder to lead an everyday life and carry on with their daily activities without the symptoms getting in their way..

The people who take Nuclona-Plus Tablet report an instant improvement in the mood and relaxation of emotion and thoughts. Depending on the dose, one might feel relief from the symptoms and overall improvement of mental health for more than 20 hours.

Nuclona-Plus Tablet contains two active ingredients: clonazepam and escitalopram oxalate.

Clonazepam is an anticonvulsant and an anxiolytic, and it belongs to a group of drugs called benzodiazepines. It relaxes the body and its muscles, controls anxiety and slows down the central nervous system. It produces a calming effect in the brain by suppressing the abnormal and exaggerated activity of nerve cells.

Escitalopram, the second ingredient, is an antidepressant. It comes under a group of drugs called SSRIs - selective serotonin reuptake inhibitors. Escitalopram is also used to reduce the signs of generalised anxiety disorder. It works by increasing the neurotransmitter serotonin to improve the mood, behaviour and cognition in patients with anxiety.

The mechanism of action of escitalopram involves the increased levels of serotonin in the intrasynaptic space. This is done by stopping the reuptake of serotonin into the presynaptic neuron.

When used together, clonazepam and escitalopram oxalate provide significant relief to patients suffering from an anxiety disorder. It calms their emotions, decreases abnormal activity in the brain, stabilises their mood and relaxes their muscles.

1. Calm your brain down: The mechanism of clonazepam

Gamma-aminobutyric acid, or GABA for short, is a neurotransmitter found in your brain. It slows and calms the brain by inhibiting specific electric signals from firing rapidly in your nervous system. Thus, Gamma-aminobutyric acid produces a calming effect, which is why medications based on this neurotransmitter are used in patients with anxiety disorders.

The way clonazepam works is by regulating GABA’s function in the nervous system, leading to enhanced GABA inhibition of neuronal firing. This stops/slows down excessive activity in the brain and eliminates the common signs in a person suffering from an anxiety disorder.

2. Living a happy life: how escitalopram works on the brain.

When we experience sadness, it is due to differences in the amounts of neurotransmitters flowing through our synapses. Antidepressants work by modifying the amounts of these chemicals and moving them from where they are to where they need to be.

Synapses are the spaces between our nerve cells (neurons) where the transmission of information happens. The neuron passing the information to the synapse is called the presynaptic neuron. The neuron that transmits this signal away from the synapse is called the postsynaptic neuron.

Two main ways antidepressants improve mood are by blocking the reabsorption of monoamines like serotonin, dopamine and noradrenaline into the presynaptic neuron; and stopping the breakdown of monoamines like serotonin, dopamine and dopamine noradrenaline in the storage spaces of the presynaptic neuron.

Escitalopram oxalate, found in Nuclona-Plus Tablet, works by blocking the reuptake or reabsorption of serotonin. That is why it comes under the class of drugs called SSRIs or selective serotonin reuptake inhibitors. When they block the reuptake, they increase the net activity of the neurotransmitter in the brain. This inhibition of the reuptake is done without affecting the level of neurotransmitters like dopamine or norepinephrine, which is why escitalopram oxalate is widely used in clinical cases.

• Clonazepam: a brief overview (ncbi.nlm.nih.gov)
• Escitalopram (medlineplus.gov)
• Escitalopram drug description (ncbi.nlm.nih.gov)