Nobel-Plus Suspension
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Introduction To Nobel-Plus Suspension
Nobel-Plus Suspension contains mefenamic acid and paracetamol, two pain-relieving medicines. It treats moderate to severe pain and is prescribed to women for dysmenorrhea and menorrhagia. This medication works by preventing the body from producing a chemical called prostaglandin. It treats symptoms like headaches, joint pain, toothache, body pain, menstrual cramps (period pain) and excessive menstrual bleeding.
Nobel-Plus Suspension should be taken as advised by your doctor; the dose may be adjusted depending on the severity of your pain. It is best to take them whole after your meal with ample water to avoid stomach discomfort. To prevent adverse effects, take it as per your doctor’s prescription.
The common side effects of Nobel-Plus Suspension include stomach discomfort, nausea, vomiting, diarrhoea, constipation, loss of appetite, bloating and ringing in the ears. They typically last for a short period and should not be of any concern. Contact your doctor if they persist or get worse.
Nobel-Plus Suspension is contraindicated for people with a history of stomach ulcers, stroke, heart failure, epilepsy, ulcerative colitis and allergies to either mefenamic acid or paracetamol. Always let your doctor know of any health conditions you might have. Generally, this combination drug is considered safe for most people.
Uses of Nobel-Plus Suspension
Nobel-Plus Suspension is a combination of two pain relievers usually prescribed to women for menstrual cramps (dysmenorrhea) and excessive bleeding (menorrhagia). It also helps alleviate all kinds of pain that one might experience, including dental pain, ear pain, headaches and fever. This medication is prescribed for joint disorders like rheumatoid arthritis and osteoarthritis as well.
Nobel-Plus Suspension consists of 2 active ingredients: mefenamic acid and paracetamol. Mefenamic acid is an NSAID (non-steroidal anti-inflammatory drug) that blocks the production of a chemical that produces pain and inflammation. When this is explicitly blocked in the uterus lining, menstrual pain is alleviated. Paracetamol reduces both temperature and pain; however, it does not have strong anti-inflammatory effects like mefenamic acid.
Nobel-Plus Suspension helps people with joint pain (rheumatoid arthritis and osteoarthritis), musculoskeletal pain (injuries or pulled muscles) and fever. It alleviates pain and most of the discomfort associated with these conditions and allows people to lead an everyday life and do their daily tasks without the hindrance of pain.
How Nobel-Plus Suspension works
This medication works by preventing the body from producing a chemical called prostaglandin. Prostaglandins are responsible for the inflammatory processes which lead to pain and fever. Thus, this medicine treats symptoms like headaches, joint pain, toothache, body pain, menstrual cramps (period pain) and excessive menstrual bleeding.
Nobel-Plus Suspension includes two active ingredients: mefenamic acid and paracetamol. Let’s look at what they do individually to understand how they work when combined.
Mefenamic acid is a non-steroidal anti-inflammatory (NSAID) medicine. It does three things in our bodies: it lowers pain, reduces inflammation and stops your temperature from increasing.
This medicine targets natural chemicals called cyclo-oxygenase enzymes, or COX enzymes for short. It blocks the effect of these enzymes (COX-1 and COX-2) and stops them from producing a substance called prostaglandins. Thus the inhibition of ‘cyclooxygenase-2-mediated prostaglandins’ occurs.
Prostaglandins are chemical substances related to pain. They are made at the site of injury or inflammation. When they are blocked or inhibited by medicines like mefenamic acid or paracetamol, the pain sensation is reduced.
Mefenamic acid is known to specifically target the synthesis of prostaglandins in the uterus lining, which is why it is prescribed for women with menstrual cramps (period pain) and excessive bleeding during periods.
Paracetamol, also known as acetaminophen, is a non-narcotic analgesic antipyretic agent – which means it reduces both pain and fever. It is believed to work by the activation of serotonergic pathways in the brain. However, compared to mefenamic Acid, it is a weak anti-inflammatory agent.
Dosage
Always take Nobel-Plus Suspension medicine as advised by your doctor. Never consume more than the prescribed daily dose. Swallow the tablet as a whole with ample water; do not chew or crush. Take this medicine after food to reduce the chances of stomach upset.
If you forget to take this medication, take it as soon as you remember. If it is time for your next dose, ignore the one you missed and continue with the next. To compensate for a missed dose, avoid taking twice the amount.
Taking more than the prescribed dose of Nobel-Plus Suspension over a long period may lead to overdose and acetaminophen intoxication. It is a serious condition in which too much paracetamol is in your body, leading to hepatotoxicity (acute hepatic necrosis) and rarely renal tubular necrosis.
If you experience signs like a change in the urine colour or severe abdominal pain, you may contact your doctor or visit the nearest hospital.
Safety Advice
Nobel-Plus Suspension is contraindicated (unsafe) for people with a history of stomach ulcers, stroke, heart failure, epilepsy, ulcerative colitis and allergies to either mefenamic acid or paracetamol. Always let your doctor know of any health conditions you might have.
PregnancyConsult doctor
Can I take Nobel-Plus Suspension if I’m pregnant?
BreastfeedingConsult doctor
Can I take Nobel-Plus Suspension if I’m breastfeeding?
AlcoholUnsafe
Is drinking alcohol while taking Nobel-Plus Suspension safe?
DrivingUnsafe
Can I drive after taking Nobel-Plus Suspension?
Drug interactions
Drug-Food interaction
Consumption of alcohol is not recommended while taking Nobel-Plus Suspension because it may cause stomach bleeding and exacerbate the medicine’s side effects like drowsiness and dizziness.
Drug-Disease interaction
Nobel-Plus Suspension might be contraindicated (unsafe) for people with a history of stomach ulcers, stroke, heart failure, epilepsy, ulcerative colitis, hyperkalemia, bleeding disorders and allergies to either mefenamic acid or paracetamol
Drug-Drug interaction
Consult your doctor if you are currently taking the following medicines: cholesterol-lowering medicine (cholestyramine), anti-sickness medicine (metoclopramide, domperidone), alcohol, antiretroviral medication (zidovudine), anticoagulants/blood thinners (warfarin, heparin), blood pressure lowering medicine (captopril), chemotherapy agent (methotrexate), antifungals (ketoconazole), cardiac glycosides (digoxin), immunosuppressant medication (ciclosporin).
Drug-Drug Interactions Checker List:
Methotrexate Warfarin Heparin Zidovudine Domperidone Metoclopramide Cholestyramine Captopril Ciclosporin Digoxin Ketoconazole
Frequently Asked Questions
Q. What is Nobel-Plus Suspension’s content?
Nobel-Plus Suspension contains mefenamic acid (NSAID) and paracetamol (analgesic). It reduces menstrual cramps, inflammation, fever and mild to moderate pain.
Q. Can I use Nobel-Plus Suspension for a headache?
Yes, Nobel-Plus Suspension can be used to relieve headaches. It contains mefenamic acid and paracetamol, two painkillers that can alleviate all kinds of general pain.
Q. Can Nobel-Plus Suspension be taken twice a day?
It is safe to take Nobel-Plus Suspension twice daily. Your doctor will prescribe the dose according to your pain. Take this tablet after food with plenty of water to minimise side effects.
Q. What is the Nobel-Plus Suspension used for?
Nobel-Plus Suspension is a combination pain medicine prescribed to treat menstrual cramps, headaches, ear pain, dental pain, body ache and joint disorders like arthritis.
Q. Is Nobel-Plus Suspension a strong painkiller?
Nobel-Plus Suspension is a painkiller used to treat mild to moderate pain and inflammations in conditions like joint pain, menstrual cramps, headaches and ear/dental pain.
Q. Should I take Nobel-Plus Suspension before food or after?
It is best to take Nobel-Plus Suspension with food to avoid side effects like stomach discomfort. Follow your doctor’s prescription for the exact dose and duration.
Q. What are the side effects of Nobel-Plus Suspension?
Nobel-Plus Suspension’s side effects include: nausea, vomiting, diarrhoea and stomach discomfort. Seek medical attention if you see signs like rashes, yellow skin or pale stools.
Q. Is Nobel-Plus Suspension and Dolo 650 the same?
No, Nobel-Plus Suspension contains two medicines (mefenamic acid and paracetamol), while Dolo 650 only includes one (paracetamol). Both are painkillers, but Nobel-Plus Suspension is stronger.
References
- Nonsteroidal Anti-inflammatory Drugs (ncbi.nlm.nih.gov)
- Mefenamic Acid (medlineplus.gov)
- Philip Anderson - Handbook of Clinical Drug Data-McGraw-Hill Medical (2001)
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Written By:
![Dr Advikka Ridhy](/assets/images/doctors/dr_advikka_ridhy.jpeg)
Dr Advikka Ridhy
MBBS
RMO, Aster MIMS
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