Neurokem D 75mg/20mg Capsule

Neurokem D 75mg/20mg Capsule is used for the treatment of neuropathic pain. It decreases pain by controlling calcium channel activity of the nerve cells. It also increases the level of chemical messengers in the brain that helps maintain mental balance and stop the movement of pain signals in the brain.

Neurokem D 75mg/20mg Capsule can be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor as this is habit forming medicine. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of the treatment even if you feel better. It is important not to stop taking this medicine suddenly as it may worsen your symptoms.

Some common side effects of this medicine include peripheral edema, nausea, headache, dryness of mouth, difficulty in concentration and blurred vision. It may cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may cause weight gain and to control it, you should have a balanced diet and exercise regularly. It is important to inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts.

Before taking this medicine let your doctor know if you suffer from kidney or liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

• Neuropathic pain

Neuropathic pain
Neurokem D 75mg/20mg Capsule is a combination of medicines used to treat long-lasting (chronic) pain caused by nerve damage due to diabetes, shingles or spinal cord injury. It reduces pain and its associated symptoms such as mood changes, sleep problems, and tiredness. Pregabalin, an active ingredient of this medicine, is thought to work by interfering with pain signals that travel through the damaged nerves and the brain. It also improves nerve conduction and enhances the quality of life.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Pregalin D

• Nausea
• Constipation
• Insomnia (difficulty in sleeping)
• Sleepiness
• Headache
• Dizziness
• Tiredness
• Ejaculation disorder
• Erectile dysfunction
• Uncoordinated body movements

Take this medicine in the dose and duration as advised by your doctor. Neurokem D 75mg/20mg Capsule may be taken with or without food, but it is better to take it at a fixed time.

Neurokem D 75mg/20mg Capsule is a combination of two medicines: Pregabalin and duloxetine. Pregabalin is an alpha 2 delta ligand which decreases pain by modulating calcium channel activity of the nerve cells. Duloxetine is a serotonin- norepinephrine reuptake inhibitor (SNRI) which increases the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain. Together, they relieve neuropathic pain (pain from damaged nerves).

• Neurokem D 75mg/20mg Capsule is used for treating nerve pain caused by diabetes, shingles, fibromyalgia, and spinal cord injuries.
• You may have to wait for 2 to 4 weeks before it starts working.
• It may cause dizziness during the first few weeks. Don't drive or do anything requiring concentration until you know how Neurokem D 75mg/20mg Capsule affects you.
• Avoid consuming alcohol when taking this medicine as it may cause excessive drowsiness and increase the risk of liver damage.
• Monitor your blood pressure regularly, especially during the first month of treatment.
• It may cause a sensation of restlessness or an inability to sit or stand still, especially when you first start taking it. Inform your doctor if this happens to you.
• Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
• Do not stop taking the medication suddenly without talking to your doctor.

Tesfaye S, Wilhelm S, Lledo A, et al. Duloxetine and pregabalin: High-dose monotherapy or their combination? The “COMBO-DN study” – a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain. Pain. 2013;154(12):2616-25. [Accessed 29 Apr. 2019] (online) Available from:

Pregabalin. Vega Baja, Puerto Rico: Pfizer Pharmaceuticals LLC; 2009. [Accessed 23 Jan. 2019] (online) Available from:

Duloxetine hydrochloride. Basingstoke, Hampshire: Eli Lilly and Company Limited; 2004 [revised 09 Nov. 2018]. [Accessed 23 Jan. 2019] (online) Available from:

Pregablin. New York, New York: Pfizer; 2004 [revised Jun 2011]. [Accessed 22 Mar. 2019] (online) Available from:

Medscape. Duloxetine. [Accessed 24 Apr. 2019] (online) Available from: