Nab-Axitaxel 100 Injection
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Introduction To Nab-Axitaxel 100 Injection
Nab-Axitaxel 100 Injection is an anti-cancer medication that may be used in combination with other medicines. It is used for the treatment of breast cancer, pancreatic cancer and non-small cell lung cancer in adults.
Nab-Axitaxel 100 Injection is given as an injection by a trained healthcare professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. It should be used exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but the treatment should not be stopped unless your doctor tells you to.
Some common side effects of this medicine include nausea, vomiting, diarrhea, and weakness. It may also cause serious side effects such as swelling of hands or lips, hair loss, and nerve problems. To reduce these side effects your doctor may suggest some medications along with it. But, inform your doctor if you notice unexplained bruising or bleeding, sore throat, mouth ulcers, high temperature (fever). This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells and liver function.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Nab-Axitaxel 100 Injection
- Treatment of Breast cancer
- Treatment of Non-small cell lung cancer
- Treatment of Pancreatic cancer
Benefits of Nab-Axitaxel 100 Injection
Treatment of Breast cancer
Nab-Axitaxel 100 Injection helps to treat breast cancer and it may be used alone or in
combination with other medicines or treatment modalities like chemotherapy. It
relieves the symptoms of breast cancer such as breast lumps, bloody discharge
from nipples or changes in the shape or texture of the breast. Nab-Axitaxel 100 Injection
kills or stops the growth of cancer cells and also prevents the multiplication
of cancer cells. Discuss with your doctor if any of the side effects bother
you.
Treatment of Non-small cell lung cancer
Non-small cell lung cancer is one of the major kinds of lung cancer and it
affects both smokers as well as non-smokers. Nab-Axitaxel 100 Injection helps treat non-small
cell lung cancer and may be given alone or in combination with other
medicines. It is a potent and very toxic medicine and you should discuss the
risks and benefits with your doctor. You should avoid drinking alcohol while
having this treatment and drink plenty of water to stay hydrated.
Treatment of Pancreatic cancer
Pancreas are very essential for digestion of whatever you eat and also for
metabolism of blood sugar levels as they produce the body’s natural insulin.
This medicine will help to control pancreatic cancer, and will relieve the
symptoms such as, lack of appetite or unexplained weight loss. Nab-Axitaxel 100 Injection
helps to stop the action of those chemicals that aid in pancreatic cancer
growth and spread. It will help you live a longer and healthier life.
Side effects of Nab-Axitaxel 100 Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Nab-Axitaxel
- Hair loss
- Decreased white blood cell count (neutrophils)
- ECG changes
- Fatigue
- Muscle pain
- Joint pain
- Increased aspartate aminotransferase
- Increased alkaline phosphatase level in blood
- Anemia (low number of red blood cells)
- Infection
- Diarrhea
- Low blood platelets
- Peripheral neuropathy (tingling and numbness of feet and hand)
- Nausea
- Vomiting
- Peripheral edema
- Fever
- Decreased appetite
- Rash
- Dehydration
How to use Nab-Axitaxel 100 Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Nab-Axitaxel 100 Injection works
Nab-Axitaxel 100 Injection is a combination of two medicines: paclitaxel and albumin. Paclitaxel, an anticancer chemical derived from plants, works by stopping cancer cells from separating into two new cells. This blocks the growth of the cancer. Albumin, a natural protein in blood, works by replacing the blood or body fluids lost due to excessive bleeding, surgery, or kidney dialysis.
Quick tips
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Nab-Axitaxel 100 Injection may cause birth defects if either the male or female is treated with it at the time of conception. You should use some kind of birth control while being treated with this medicine and for at least 12 weeks after you stop using it.
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If you receive Nab-Axitaxel 100 Injection in combination with gemcitabine, infections can be severe and lead to death. Tell your doctor immediately if you have a fever (temperature greater than 100.4° F) or develop signs of infection.
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Be careful when using a toothbrush, toothpick, or dental floss. Your doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Also, avoid contact sports or other situations where you may bruise or get injured since this medicine increases the risk of bleeding.
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To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.
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Decreased sensation, numbness, and tingling in fingers and toes may worsen with repeated doses of this medicine. Protect yourself from injury if you have numb hands or feet, and report this to your doctor.
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If you are undergoing any surgery, let the surgeon or anesthetist know that you are being treated with Nab-Axitaxel 100 Injection since it may affect other medicines used during surgery.
Safety Advice
PregnancyCONSULT YOUR DOCTOR
Can I take Nab-Axitaxel 100 Injection if I’m pregnant?
Nab-Axitaxel 100 Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
BreastfeedingCONSULT YOUR DOCTOR
Can I take Nab-Axitaxel 100 Injection if I’m breastfeeding?
Information regarding the use of Nab-Axitaxel 100 Injection during breastfeeding is not available. Please consult your doctor.
AlcoholCONSULT YOUR DOCTOR
Is drinking alcohol while taking Nab-Axitaxel 100 Injection safe?
It is not known whether it is safe to consume alcohol with Nab-Axitaxel 100 Injection. Please consult your doctor.
DrivingCONSULT YOUR DOCTOR
Can I drive after taking Nab-Axitaxel 100 Injection?
It is not known whether Nab-Axitaxel 100 Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
KidneyCONSULT YOUR DOCTOR
Can I take Nab-Axitaxel 100 Injection if I have/had kidney diseases?
There is limited information available on the use of Nab-Axitaxel 100 Injection in patients with kidney disease. Please consult your doctor.
LiverCAUTION
Can I take Nab-Axitaxel 100 Injection if I have/had liver diseases?
Nab-Axitaxel 100 Injection should be used with caution in patients with liver disease. Dose adjustment of Nab-Axitaxel 100 Injection may be needed. Please consult your doctor.
Frequently Asked Questions
Q. How is Nab-Axitaxel 100 Injection given?
Nab-Axitaxel 100 Injection is administered into the vein by intravenous (IV) injection over 30 minutes.
Q. For how long is Nab-Axitaxel 100 Injection given?
Nab-Axitaxel 100 Injection is given as per the condition being treated: a. Breast cancer: It is usually given once every three weeks (i.e. on day 1 of a 21-day cycle). Each injection is called one 'cycle' of chemotherapy. Your doctor will decide how many of these cycles you will need. b. Lung cancer: It is given every week (i.e. on days 1, 8, and 15 of each 21-day cycle). Another medicine called carboplatin is also given on day 1 only of each 21-day cycle. Your doctor will decide how many of these cycles, you will need. c. Pancreatic cancer: It is given every week (i.e. on days 1, 8, and 15 of each 28-day cycle). Every 28 days is called one ‘cycle’ of chemotherapy. Another medicine called gemcitabine is also given on days 1, 8, and 15 after Nab-Axitaxel 100 Injection has been given. Your doctor will decide how many of these cycles you will need.
Q. Does Nab-Axitaxel 100 Injection cause hair loss?
Yes, while taking this medicine, your hair may become brittle and break. You may also experience patchy hair loss or thinning. These conditions tend to resolve once the treatment is stopped. Be gentle when brushing and washing hair to manage hair loss.
Q. How to get relief from diarrhea while on treatment with Nab-Axitaxel 100 Injection?
Food items with soluble fiber can help relieve diarrhea as they help absorb excess fluid from the body. These food items include bananas (ripe), oranges, boiled potatoes, white rice, curd, and oatmeal. Diarrhea can cause dehydration in the body; therefore, drink 8-10 glasses of water to avoid dehydration. You can also have soups and juices frequently to hydrate yourself.
Q. Should I avoid any food and drinks while taking Nab-Axitaxel 100 Injection?
You can continue with your normal diet unless your doctor tells otherwise. However, it is advisable to sip water regularly to prevent dehydratration, eat small, simple but nourishing snacks every few hours rather than large meals, and suck on hard candy or popsicles to prevent nausea and vomiting.
Q. I have noticed some changes in my skin after taking Nab-Axitaxel 100 Injection?
What should I do? Use a moisturizer to get relief from rashes and dry and itchy skin. Avoid direct sunlight, wear protective clothing, and use sunscreen (SPF of more than 15) whenever you step outdoors. Do not go swimming if you have a rash because the chlorine in the water can make it worse. Avoid hot water baths and wear loose and cotton fabric clothes. Your skin will tend to become better once the treatment is stopped.
Q. Are there any precautions for a tingling sensation and numbness in my arms and legs?
This medicine causes tingling, numbness, pain, or burning sensation in your arms or legs. Be careful when moving around, as the numbness may make it harder to walk, feel your hands or feet, or increase your risk of falls. Talk to your doctor if you feel these symptoms. You doctor may change your dose or schedule.
Q. How to cope with tiredness and weakness after starting the treatment with Nab-Axitaxel 100 Injection?
Various things can help you to reduce tiredness and cope with it, for example, gentle exercise. Always consult your doctor before doing any kind of exercise. Also, avoid driving or operating any machines soon after taking Nab-Axitaxel 100 Injection in case you feel tired or dizzy.
Q. Can I take any other vaccination while on treatment with Nab-Axitaxel 100 Injection?
No, it is not advisable to take any other vaccinations without consulting your doctor while taking Nab-Axitaxel 100 Injection.
Q. What precautions should I take to protect other people while on treatment with Nab-Axitaxel 100 Injection?
Your body breaks down Nab-Axitaxel 100 Injection and uses it to fight cancer. The breakdown products may be excreted in body fluids and waste, including blood, urine, feces, vomitus, and semen. Thus, it is important to follow certain precautionary measures while you are receiving chemotherapy and for one week after the treatment period by: a. Flush the toilet twice to dispose of any body fluids and waste. b. Wash linen or clothing that is contaminated by body fluids or wastes separately. c. Place soiled disposable diapers and other pads in a plastic bag, and seal and dispose them into the garbage. c. For sexual intercourse, use a barrier contraceptive method, such as a condom.
References
Written By:
Dr Advikka Ridhy
MBBS
RMO, Aster MIMS
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