Minirin Nasal Spray

Minirin Nasal Spray is used in the treatment of diabetes insipidus and bed-wetting. This medicine helps decrease the urge to urinate and help resume more normal life-style. It is generally used in patients who cannot take the oral form of medicine.

Minirin Nasal Spray should be used as you have been advised by your doctor. Normally you should blow your nose gently before using it, keep one nostril closed while applying the medicine into the other and then sniff hard to make sure it reaches deep into the nose. Then repeat for the other nostril.

The most common side effects are irritation or discomfort to the nose and sneezing. These are usually mild but if they bother you or do not go away, your doctor may be able to suggest ways of preventing or reducing them.

It is generally a safe medicine but, before taking it, talk to your doctor about any health problems you have such as heart problems or high blood pressure (hypertension) or overactive thyroid gland or glaucoma or prostate enlargement. Let your doctor know about any other medicines you are taking to make sure you are safe. Ask your doctor for advice before using this medicine if you are pregnant or breastfeeding.

• Diabetes insipidus
• Bed-wetting

Diabetes insipidus
Minirin Nasal Spray is given as a nasal spray as its absorption is greatly increased when taken through the nose and it brings about rapid action of controlling thirst and also reduces the urge to urinate often. This helps to manage these symptoms in diabetes insipidus.

Bed-wetting
Minirin Nasal Spray contains a hormone vasopressin, that acts on the kidneys and reduces the frequency and amount of urine produced by the kidneys. This helps to treat bedwetting in children. Bedwetting can be uncomfortable as well as embarrassing for the children and also their parents. Taking Minirin Nasal Spray does not cure the condition but prevents bedwetting effectively till the child is on treatment with it.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Dpressin

• Nasal discomfort
• Nasopharyngitis (inflammation of the throat and nasal passages)
• Nasal congestion (stuffy nose)
• Sneezing
• Back pain
• Nosebleeds
• Bronchitis (inflammation of the airways)
• Dizziness

Use this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Insert the bottle tip into one nostril and close the other nostril. Direct the spray towards the sides of your nostril, away from the cartilage dividing the two sides of your nose. As you spray, breath gently and keep the head upright. Repeat the same process for the other nostrils.

Minirin Nasal Spray is a synthetic form of vasopressin (natural hormone that balances water). It is rapidly absorbed into the bloodstream through the inner surface of the nose. Once absorbed, it works by causing reabsorption of water from the kidneys which controls excessive thirst and urination in diabetes insipidus. It also helps decrease night-time urine production in multiple sclerosis.

• The right way to use the nasal spray:

  • Shake the bottle before using the medicine.
  • Clean your nose thoroughly before using the medicine.
  • Insert the bottle tip into one nostril and close the other nostril.
  • Direct the spray towards the sides of your nostril, away from the cartilage dividing the two sides of your nose.
  • Breathe out gently through your mouth and repeat the same process for the other nostril.

• Limit the amount of fluids you drink with this medication.

• Do not share the bottle with anyone else so that you do not spread germs.

• Use the Minirin Nasal Spray within 4 weeks of opening it and discard the rest.

Reilly RF, Jackson EK. Regulation of Renal Function and Vascular Volume. In: Brunton LL, Chabner BA, Knollmann BC,12th ed. editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 712-14.

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 375.

Medlineplus. Desmopressin Nasal. [Accessed 04 Apr. 2019] (online) Available from:

Desmopressin. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC; 2007. [Accessed 04 Apr. 2019] (online) Available from:

Central Drugs Standard Control Organisation (CDSCO). [Accessed 3 Apr. 2019] (online) Available from: