Mefrin Forte 500mg/450mg Tablet

MRP
₹ 25
PRESCRIPTION REQUIRED
YES
MANUFACTURER/ MARKETER
Rhine Biogenics Pvt Ltd
QUANTITY
10 tablets

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Introduction To Mefrin Forte 500mg/450mg Tablet

Mefrin Forte 500mg/450mg Tablet contains mefenamic acid and paracetamol, two pain-relieving medicines. It treats moderate to severe pain and is prescribed to women for dysmenorrhea and menorrhagia. This medication works by preventing the body from producing a chemical called prostaglandin. It treats symptoms like headaches, joint pain, toothache, body pain, menstrual cramps (period pain) and excessive menstrual bleeding.

Mefrin Forte 500mg/450mg Tablet should be taken as advised by your doctor; the dose may be adjusted depending on the severity of your pain. It is best to take them whole after your meal with ample water to avoid stomach discomfort. To prevent adverse effects, take it as per your doctor’s prescription.

The common side effects of Mefrin Forte 500mg/450mg Tablet include stomach discomfort, nausea, vomiting, diarrhoea, constipation, loss of appetite, bloating and ringing in the ears. They typically last for a short period and should not be of any concern. Contact your doctor if they persist or get worse.

Mefrin Forte 500mg/450mg Tablet is contraindicated for people with a history of stomach ulcers, stroke, heart failure, epilepsy, ulcerative colitis and allergies to either mefenamic acid or paracetamol. Always let your doctor know of any health conditions you might have. Generally, this combination drug is considered safe for most people.

Uses of Mefrin Forte 500mg/450mg Tablet

Mefrin Forte 500mg/450mg Tablet is a combination of two pain relievers usually prescribed to women for menstrual cramps (dysmenorrhea) and excessive bleeding (menorrhagia). It also helps alleviate all kinds of pain that one might experience, including dental pain, ear pain, headaches and fever. This medication is prescribed for joint disorders like rheumatoid arthritis and osteoarthritis as well.

Mefrin Forte 500mg/450mg Tablet consists of 2 active ingredients: mefenamic acid and paracetamol. Mefenamic acid is an NSAID (non-steroidal anti-inflammatory drug) that blocks the production of a chemical that produces pain and inflammation. When this is explicitly blocked in the uterus lining, menstrual pain is alleviated. Paracetamol reduces both temperature and pain; however, it does not have strong anti-inflammatory effects like mefenamic acid.

Mefrin Forte 500mg/450mg Tablet helps people with joint pain (rheumatoid arthritis and osteoarthritis), musculoskeletal pain (injuries or pulled muscles) and fever. It alleviates pain and most of the discomfort associated with these conditions and allows people to lead an everyday life and do their daily tasks without the hindrance of pain.

How Mefrin Forte 500mg/450mg Tablet works

This medication works by preventing the body from producing a chemical called prostaglandin. Prostaglandins are responsible for the inflammatory processes which lead to pain and fever. Thus, this medicine treats symptoms like headaches, joint pain, toothache, body pain, menstrual cramps (period pain) and excessive menstrual bleeding.

Mefrin Forte 500mg/450mg Tablet includes two active ingredients: mefenamic acid and paracetamol. Let’s look at what they do individually to understand how they work when combined.

Mefenamic acid is a non-steroidal anti-inflammatory (NSAID) medicine. It does three things in our bodies: it lowers pain, reduces inflammation and stops your temperature from increasing.

This medicine targets natural chemicals called cyclo-oxygenase enzymes, or COX enzymes for short. It blocks the effect of these enzymes (COX-1 and COX-2) and stops them from producing a substance called prostaglandins. Thus the inhibition of ‘cyclooxygenase-2-mediated prostaglandins’ occurs.

Prostaglandins are chemical substances related to pain. They are made at the site of injury or inflammation. When they are blocked or inhibited by medicines like mefenamic acid or paracetamol, the pain sensation is reduced.

Mefenamic acid is known to specifically target the synthesis of prostaglandins in the uterus lining, which is why it is prescribed for women with menstrual cramps (period pain) and excessive bleeding during periods.

Paracetamol, also known as acetaminophen, is a non-narcotic analgesic antipyretic agent – which means it reduces both pain and fever. It is believed to work by the activation of serotonergic pathways in the brain. However, compared to mefenamic Acid, it is a weak anti-inflammatory agent.

Dosage

Always take Mefrin Forte 500mg/450mg Tablet medicine as advised by your doctor. Never consume more than the prescribed daily dose. Swallow the tablet as a whole with ample water; do not chew or crush. Take this medicine after food to reduce the chances of stomach upset.

If you forget to take this medication, take it as soon as you remember. If it is time for your next dose, ignore the one you missed and continue with the next. To compensate for a missed dose, avoid taking twice the amount.

Taking more than the prescribed dose of Mefrin Forte 500mg/450mg Tablet over a long period may lead to overdose and acetaminophen intoxication. It is a serious condition in which too much paracetamol is in your body, leading to hepatotoxicity (acute hepatic necrosis) and rarely renal tubular necrosis.

If you experience signs like a change in the urine colour or severe abdominal pain, you may contact your doctor or visit the nearest hospital.

Safety Advice

Mefrin Forte 500mg/450mg Tablet is contraindicated (unsafe) for people with a history of stomach ulcers, stroke, heart failure, epilepsy, ulcerative colitis and allergies to either mefenamic acid or paracetamol. Always let your doctor know of any health conditions you might have.

sdsPregnancyConsult doctor

Can I take Mefrin Forte 500mg/450mg Tablet if I’m pregnant?

sdsBreastfeedingConsult doctor

Can I take Mefrin Forte 500mg/450mg Tablet if I’m breastfeeding?

sdsAlcoholUnsafe

Is drinking alcohol while taking Mefrin Forte 500mg/450mg Tablet safe?

sdsDrivingUnsafe

Can I drive after taking Mefrin Forte 500mg/450mg Tablet?

Drug interactions

Drug-Food interaction

Consumption of alcohol is not recommended while taking Mefrin Forte 500mg/450mg Tablet because it may cause stomach bleeding and exacerbate the medicine’s side effects like drowsiness and dizziness.

Drug-Disease interaction

Mefrin Forte 500mg/450mg Tablet might be contraindicated (unsafe) for people with a history of stomach ulcers, stroke, heart failure, epilepsy, ulcerative colitis, hyperkalemia, bleeding disorders and allergies to either mefenamic acid or paracetamol

Drug-Drug interaction

Consult your doctor if you are currently taking the following medicines: cholesterol-lowering medicine (cholestyramine), anti-sickness medicine (metoclopramide, domperidone), alcohol, antiretroviral medication (zidovudine), anticoagulants/blood thinners (warfarin, heparin), blood pressure lowering medicine (captopril), chemotherapy agent (methotrexate), antifungals (ketoconazole), cardiac glycosides (digoxin), immunosuppressant medication (ciclosporin).

Drug-Drug Interactions Checker List:

Methotrexate Warfarin Heparin Zidovudine Domperidone Metoclopramide Cholestyramine Captopril Ciclosporin Digoxin Ketoconazole

Frequently Asked Questions

Q. What is Mefrin Forte 500mg/450mg Tablet’s content?

Mefrin Forte 500mg/450mg Tablet contains mefenamic acid (NSAID) and paracetamol (analgesic). It reduces menstrual cramps, inflammation, fever and mild to moderate pain.

Q. Can I use Mefrin Forte 500mg/450mg Tablet for a headache?

Yes, Mefrin Forte 500mg/450mg Tablet can be used to relieve headaches. It contains mefenamic acid and paracetamol, two painkillers that can alleviate all kinds of general pain.

Q. Can Mefrin Forte 500mg/450mg Tablet be taken twice a day?

It is safe to take Mefrin Forte 500mg/450mg Tablet twice daily. Your doctor will prescribe the dose according to your pain. Take this tablet after food with plenty of water to minimise side effects.

Q. What is the Mefrin Forte 500mg/450mg Tablet used for?

Mefrin Forte 500mg/450mg Tablet is a combination pain medicine prescribed to treat menstrual cramps, headaches, ear pain, dental pain, body ache and joint disorders like arthritis.

Q. Is Mefrin Forte 500mg/450mg Tablet a strong painkiller?

Mefrin Forte 500mg/450mg Tablet is a painkiller used to treat mild to moderate pain and inflammations in conditions like joint pain, menstrual cramps, headaches and ear/dental pain.

Q. Should I take Mefrin Forte 500mg/450mg Tablet before food or after?

It is best to take Mefrin Forte 500mg/450mg Tablet with food to avoid side effects like stomach discomfort. Follow your doctor’s prescription for the exact dose and duration.

Q. What are the side effects of Mefrin Forte 500mg/450mg Tablet?

Mefrin Forte 500mg/450mg Tablet’s side effects include: nausea, vomiting, diarrhoea and stomach discomfort. Seek medical attention if you see signs like rashes, yellow skin or pale stools.

Q. Is Mefrin Forte 500mg/450mg Tablet and Dolo 650 the same?

No, Mefrin Forte 500mg/450mg Tablet contains two medicines (mefenamic acid and paracetamol), while Dolo 650 only includes one (paracetamol). Both are painkillers, but Mefrin Forte 500mg/450mg Tablet is stronger.

References

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