Historest 1mg/125mg/2.5mg Tablet

Historest 1mg/125mg/2.5mg Tablet is a combination medicine for treating the common cold, fever, and flu symptoms. It contains chlorpheniramine maleate (which lowers allergic reactions), paracetamol (which lowers pain and fever), and phenylephrine (which reduces nasal congestion). They relieve symptoms such as runny or stuffy nose, sneezing, watery eyes, and itchy throat. Your doctor may prescribe this medication for the common cold, hay fever/rhinitis, seasonal allergies, and flu.

Historest 1mg/125mg/2.5mg Tablet should be taken as advised by your doctor. The dosage may be adjusted depending on your pain level. You can take it before or after eating. To prevent adverse effects, take it as per your doctor’s prescription.

Side effects of Historest 1mg/125mg/2.5mg Tablet can include drowsiness, headache, nausea, loss of appetite, constipation, vomiting, and dry mouth. They usually don't last long and often go away by themselves. If they continue, talk to your doctor.

Historest 1mg/125mg/2.5mg Tablet is contraindicated (unsafe) for people who are lactating and hypersensitive to chlorpheniramine maleate, paracetamol, or phenylephrine. Always inform your doctor of medical conditions like heart and liver disease. Generally, this combination drug is considered safe for most people.

Historest 1mg/125mg/2.5mg Tablet contains three ingredients: chlorpheniramine maleate (allergy medication), paracetamol (pain and fever medication), and phenylephrine (nasal decongestant). They relieve symptoms such as sore throat, headache, runny nose, muscular pain, and fever.

Phenylephrine, the first ingredient in Historest 1mg/125mg/2.5mg Tablet, is a synthetic direct-acting adrenergic agonist. It acts on adrenergic receptors that affect the contraction of blood vessels. When we take this medicine, these receptors are activated, resulting in the shrinkage of dilated/swollen blood vessels. This effect inside the sinus and nasal cavity reduces nasal congestion and relieves symptoms like a stuffy nose.

Paracetamol, also known as acetaminophen, is the second ingredient in this combination. It is an analgesic (treats pain) and an antipyretic (treats fever) agent. It works by targeting cyclooxygenase-mediated prostaglandin synthesis in the brain.

Historest 1mg/125mg/2.5mg Tablet also contains chlorpheniramine maleate, an H1-receptor antagonist. It is an antihistamine that works against chemicals called histamines. This chemical is responsible for most of the allergic responses, such as coughing, sneezing, vomiting, and runny nose, which are means of getting rid of allergens from the body.

People with severe allergies experience these symptoms due to the exaggerated function of these histamines. The histamines work by binding with the H1 receptors in our body. That is why chlorpheniramine maleate is prescribed for people with the cold and flu; it competitively inhibits the interaction of histamine with its H1 receptors, ridding patients of their allergic symptoms.

<p><a href="https://medlineplus.gov/druginfo/meds/a682543.html">Chlorpheniramine (medlineplus.gov)<br /></a><a href="https://medlineplus.gov/druginfo/meds/a606008.html">Phenylephrine (medlineplus.gov)</a></p> <p><a href="https://medlineplus.gov/druginfo/meds/a681004.html">Paracetamol (medlineplus.gov)</a></p> <p><a href="https://www.nhs.uk/conditions/decongestants/">Nasal decongestants (</a><a href="http://www.nhs.uk">www.nhs.uk</a><a href="https://www.nhs.uk/conditions/decongestants/">)</a></p>