Glomatinib 400mg Tablet
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Introduction To Glomatinib 400mg Tablet
Glomatinib 400mg Tablet belongs to the class of medicines known as tyrosine kinase inhibitors. It is used in the treatment of blood cancer (chronic myeloid leukaemia and Acute lymphocytic leukemia) and gastrointestinal stromal tumor.
Glomatinib 400mg Tablet should be taken with food, but better to have it same time every day to get the most benefit. You should continue to take it as long as your doctor advises for it. The duration of treatment varies according to your need and response to treatment. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include edema, nausea, vomiting, muscle cramps, musculoskeletal pain, diarrhea, rash, fatigue, and abdominal pain. Let your doctor know if you experience unexpected rapid weight gain. Your doctor may advise for regular monitoring of blood cells and liver function while you are taking this medicine. Do not drive or do anything requiring mental focus if you experience dizziness and blurry vision.
Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Glomatinib 400mg Tablet
- Blood cancer (Chronic myeloid leukaemia)
- Blood cancer (Acute lymphocytic leukemia)
- Gastrointestinal stromal tumour
Benefits of Glomatinib 400mg Tablet
Blood cancer (Chronic myeloid leukaemia)
Blood cancer, also called leukemia, is a cancer of the blood-forming tissues,
that decreases the body's ability to fight infection. Glomatinib 400mg Tablet kills or
stops the growth of cancer cells and also prevents the multiplication of
cancer cells. It is a potent and very toxic medicine and you should discuss
the risks and benefits with your doctor. You should avoid drinking alcohol
while having this treatment and drink plenty of water to stay hydrated.
Blood cancer (Acute lymphocytic leukemia)
Blood cancer, also called leukemia, is a cancer of the blood-forming tissues,
that decreases the body's ability to fight infection. Glomatinib 400mg Tablet kills or
stops the growth of cancer cells and also prevents the multiplication of
cancer cells. It is a potent and very toxic medicine and you should discuss
the risks and benefits with your doctor. You should avoid drinking alcohol
while having this treatment and drink plenty of water to stay hydrated.
Gastrointestinal stromal tumour
A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs most
commonly in the stomach or small intestine. The tumors develop into the
specialized cells called interstitial cells of Cajal (ICCs). Glomatinib 400mg Tablet helps
to kill the cancer cells and also stops their further growth and spread.
Follow your doctor’s instructions carefully to get the most benefit.
Side effects of Glomatinib 400mg Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Chemotinib
- Edema (swelling)
- Nausea
- Vomiting
- Muscle cramp
- Musculoskeletal (bone, muscle or joint) pain
- Diarrhea
- Rash
- Fatigue
- Abdominal pain
How to use Glomatinib 400mg Tablet
Take this medicine in the dose and duration as advised by your doctor. Glomatinib 400mg Tablet is to be taken with food.
How Glomatinib 400mg Tablet works
Glomatinib 400mg Tablet is an anti-cancer medication. A protein enzyme, bcr-abl tyrosine kinase, responsible for the growth of abnormal proliferation of cancer cells. This medicine inhibits the proliferation and induces apoptosis (planned cell death) in bcr-abl positive cells (cancer cells). This is how it works to stop or slow the spread of cancer.
Quick tips
- Always take it with food and a full glass of water to prevent nausea.
- It may cause dizziness or blurred vision. Do not drive or do anything requiring concentration until you know how it affects you.
- Water retention and swelling are very common side effects of Glomatinib 400mg Tablet. Notify your doctor if you have unexpected rapid weight gain.
- Do not change the dose or discontinue use without consulting your doctor.
- Notify your doctor about all the medications you are taking, including over the counter medicines and dietary supplements.
- Your doctor may get regular blood tests done to monitor your liver function and the number of blood cells in your blood.
Safety Advice
PregnancyCONSULT YOUR DOCTOR
Can I take Glomatinib 400mg Tablet if I’m pregnant?
Glomatinib 400mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
BreastfeedingCONSULT YOUR DOCTOR
Can I take Glomatinib 400mg Tablet if I’m breastfeeding?
Glomatinib 400mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. Lactating women should not breastfeed while using this drug and one month after stopping it.
AlcoholCONSULT YOUR DOCTOR
Is drinking alcohol while taking Glomatinib 400mg Tablet safe?
It is not known whether it is safe to consume alcohol with Glomatinib 400mg Tablet. Please consult your doctor.
DrivingUNSAFE
Can I drive after taking Glomatinib 400mg Tablet?
Glomatinib 400mg Tablet may cause side effects which could affect your ability to drive.
KidneyCAUTION
Can I take Glomatinib 400mg Tablet if I have/had kidney diseases?
Glomatinib 400mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Glomatinib 400mg Tablet may be needed. Please consult your doctor.
LiverCAUTION
Can I take Glomatinib 400mg Tablet if I have/had liver diseases?
Glomatinib 400mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Glomatinib 400mg Tablet may be needed. Please consult your doctor.
Frequently Asked Questions
Q. Can Glomatinib 400mg Tablet be taken with food?
Yes, the best way to take it is with a glass of water and food. This prevents irritation in the food pipe and stomach. If you cannot swallow it, put the tablets in a glass of water or apple juice (approximately 50 ml for a 100 mg tablet and 200 ml for a 400 mg tablet). Stir it with a spoon to make it uniform and drink it immediately.
Q. Is it safe to drive while taking Glomatinib 400mg Tablet?
Glomatinib 400mg Tablet may cause dizziness, lightheadedness or drowsiness in some people. Make sure you know how you react to it before you drive a car or operate machinery.
Q. What precautions need to be followed while taking Glomatinib 400mg Tablet?
While taking Glomatinib 400mg Tablet, make sure you follow all the instructions given by your doctor, carefully and keep all appointments. You will need regular follow-up to ensure that the treatment is working. Regular blood tests, weight checks, and urine tests may be required to find out any side effects before it becomes serious. Make sure you use a method of contraception to prevent pregnancy during treatment with Glomatinib 400mg Tablet. Tell your doctor immediately if you become pregnant while you are taking this medicine. If you are about to start taking any new medicine, remind your doctor that you are taking Glomatinib 400mg Tablet. Q. Q. Ever since I started using Glomatinib 400mg Tablet, I have noticed that I develop rashes and severe itching when I have sun exposure. Is it because of the medicine or the disease? This medicine may make your skin much more sensitive to sunlight than it normally is. Exposure to sunlight may cause skin rash, itching, redness or severe sunburn. When you are outdoors, wear protective clothing and use a sunscreen with an SPF of 15 or higher. If you feel a burning sensation on your skin, tell your doctor. Q. Q. The doctor has advised me not to take any medicine on my own while taking Glomatinib 400mg Tablet. Should I consult my doctor even if I need to take paracetamol for my fever? Yes, there are a number of medicines which interfere with Glomatinib 400mg Tablet, including paracetamol. Therefore you should not self medicate while taking Glomatinib 400mg Tablet. Other medicines which interfere with Glomatinib 400mg Tablet include cyclosporin, dexamethasone (a steroid), warfarin, antiviral medicines which treat AIDS and some medicines which treat bacterial infections, high cholesterol, high blood pressure, heart problems, and mental disorders and depression. Consult your doctor before taking any medicine, and inform him that you are on Glomatinib 400mg Tablet therapy.
Q. What precautions need to be followed while taking Glomatinib 400mg Tablet?
While taking Glomatinib 400mg Tablet, make sure you follow all the instructions given by your doctor, carefully and keep all appointments. You will need regular follow-up to ensure that the treatment is working. Regular blood tests, weight checks, and urine tests may be required to find out any side effects before it becomes serious. Make sure you use a method of contraception to prevent pregnancy during treatment with Glomatinib 400mg Tablet. Tell your doctor immediately if you become pregnant while you are taking this medicine. If you are about to start taking any new medicine, remind your doctor that you are taking Glomatinib 400mg Tablet.
Q. Can I expect that if I take Glomatinib 400mg Tablet regularly and as advised by the doctor for CML, I will be cured?
Glomatinib 400mg Tablet has proved effective in many cases of CML. It is also noticed that the chances of survival increase after taking this medicine. The doctor who is treating CML can tell you better. The doctor will analyze your current state, blood test results, response to treatment, any other medical illness which you may be having, etc. and tell you.
References
Substitutes:
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Chemotinib 400mg Tablet
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Imatib 400 Tablet
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Written By:
Dr Advikka Ridhy
MBBS
RMO, Aster MIMS
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