Glofty-OZ Suspension

Glofty-OZ Suspension is used to treat bacterial and protozoan infections of the lungs, skin, reproductive system and gastrointestinal tract. This drug is a combination of two antibiotics: Ofloxacin and ornidazole. The first kills bacteria, while the latter kills parasitic organisms called protozoa. This medication can be prescribed for pneumonia, urethritis, dysentery, amebiasis, giardiasis and other microbial infections.

Glofty-OZ Suspension should be taken as advised by your doctor. It is best to take them whole after your meal with plenty of fluids to avoid stomach discomfort. All antibiotic therapies should be completed and not stopped midway, even if you feel well. Try not to miss a dose, and avoid taking twice the amount to compensate for a missed dose.

Side effects of Glofty-OZ Suspension include nausea, tiredness, dry mouth and headache. They typically last for a short period and should not be of any concern. Your doctor may also prescribe a PPI medicine (drugs that reduce stomach acid) along with the antibiotic to counter its gastric side effects.

Glofty-OZ Suspension is contraindicated for people with a history of liver diseases, renal failure, nerve disorders, and allergies to either ofloxacin or ornidazole. Always let your doctor know of any health conditions you might have. Generally, this combination drug is considered safe for most people.

Glofty-OZ Suspension contains two antibiotics used in the treatment of bacterial infections and protozoan diseases. These infections affect various parts of the body, including the lungs, urinary tract, skin, reproductive system and gastrointestinal tract.

This medication is prescribed for the following:

Glofty-OZ Suspension is a combination of two antimicrobial drugs: an antibiotic and an antiprotozoal. When administered together, both kill the harmful bacteria and protozoan parasites by blocking certain enzymes and producing toxic compounds that kill the infective agent.

Glofty-OZ Suspension includes two active ingredients: ofloxacin and ornidazole. Let’s look at what they do individually to understand how they work when combined.

Ofloxacin is an antibiotic that comes under the class of antibiotic drugs called fluoroquinolones. They work as broad-spectrum drugs (which means they are functional against a wide range of bacteria) and are used to kill both gram-positive and gram-negative bacteria.

The way ofloxacin works is by preventing the bacterial cells from multiplying. It blocks or inhibits certain enzymes within the bacterial cell, such as DNA gyrase, type II topoisomerase, and topoisomerase IV enzymes. These enzymes are necessary for the separation of bacterial DNA, which is crucial for cell division. When these enzymes are blocked, the DNA breaks, and the bacteria die.

Ornidazole is a nitroimidazole antimicrobial. It works against both parasites (protozoans) and anaerobic bacteria. The mechanism of action involves the activation of this drug by the enzymes the microbes produce; upon activation, certain toxic compounds are formed, which are harmful to the cells of these microbes. This results in the damage of proteins, membranes and the DNA found inside the cell.

Ornidazole is used to treat trichomoniasis (a sexually transmitted disease caused by Trichomonas vaginalis), giardiasis (a diarrheal disease caused by Giardia duodenalis), and amebiasis (an intestinal infection caused by Entamoeba histolytica) - all protozoal infections.

• Ofloxacin: a brief overview (medlineplus.gov)
• Ornidazole (pubchem.ncbi.nlm.nih.gov)