Epizeal 333mg/145mg Tablet CR

Epizeal 333mg/145mg Tablet CR is a combination of two medicines used to treat epilepsy, a neurological disorder in which there are recurrent episodes of seizures or fits. It controls the abnormal activity of the brain, relaxes the nerves and hence, prevents seizures or fits.

Epizeal 333mg/145mg Tablet CR should be taken with food. Your doctor will decide the correct dose for you. This may increase gradually until your condition is stable. This medicine may take several weeks to work but it is important to take it regularly to get the benefit. Do not stop taking it, even if you feel fine unless your doctor advises you to. You may have more seizures, or your bipolar disorder may get worse.

The most common side effects of this medicine include nausea, vomiting, loss of appetite, swelling of gums, headache, sleepiness, tremor, hair loss and liver injury. Most side effects wear off, but if they bother you or do not go away, tell your doctor. There may be ways of preventing or reducing these effects.

Before taking this medicine, tell your doctor if you have kidney or liver problems, meningitis or depression or suicidal thoughts. Also let your doctor know about all other medications you are using as some may affect, or be affected by, this medicine, including contraceptive pills. If you are pregnant or breastfeeding, Epizeal 333mg/145mg Tablet CR can be taken if it is clearly needed but the dose may be adjusted. You should avoid driving or riding a bicycle if this medicine makes you drowsy or dizzy. You may need frequent blood tests to check how you are responding to this medicine.

You should avoid alcohol while taking Epizeal 333mg/145mg Tablet CR, as it may worsen certain side effects. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.

• Epilepsy

Epilepsy
Epizeal 333mg/145mg Tablet CR slows down electrical signals in the brain which cause seizures (fits). It can also help reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety. The medicine can allow you to do some activities that you would otherwise be forbidden or scared to do (such as swimming and driving). It can take a few weeks for this medicine to work (because the dose has to be increased slowly) and during this time you may still have seizures. Do not stop using this medicine even if you feel well, until your doctor advises you to. Missing doses may trigger a seizure.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Epima Chrono

• Nausea
• Vomiting
• Weight gain
• Loss of appetite
• Gum swelling
• Headache
• Sleepiness
• Tremors
• Hair loss
• Liver injury

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Epizeal 333mg/145mg Tablet CR is to be taken with food.

Epizeal 333mg/145mg Tablet CR is a combination of two antiepileptic medicines: Sodium Valproate and Valproic Acid. They work together to control seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.

• You have been prescribed Epizeal 333mg/145mg Tablet CR for treatment and prevention of seizures.
• Take it at the same time every day to maintain consistent levels in your body.
• Do not drive or do anything that requires mental focus until you know how Epizeal 333mg/145mg Tablet CR affects you.
• Avoid consuming alcohol when taking Epizeal 333mg/145mg Tablet CR, as it may cause excessive sleepiness or drowsiness.
• Monitor your weight during the treatment as Epizeal 333mg/145mg Tablet CR can cause weight gain.
• Your doctor may monitor Epizeal 333mg/145mg Tablet CR level, blood counts and liver function regularly throughout your treatment. Inform your doctor if you develop fever, stomach pain, nausea or yellowing of your eyes or skin.
• Do not take Epizeal 333mg/145mg Tablet CR if you are pregnant or planning to conceive or breastfeeding.
• Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.

Linde M, Mulleners WM, Chronicle EP, et al. Valproate (valproic acid or sodium valproate or a combination of the two) for the prophylaxis of episodic migraine in adults. Cochrane Database Syst Rev. 2013;(6):CD010611. [Accessed 23 Apr. 2019] (online) Available from:

Drugs.com. Sodium Valporate. [Accessed 23 Apr. 2019] (online) Available from:

Drugs.com. Valporic acid. [Accessed 23 Apr. 2019] (online) Available from: