Dulocent 325 mg/37.5 mg Tablet

Dulocent 325 mg/37.5 mg Tablet is a combination medicine (paracetamol and tramadol) for pain relief. It is used to treat moderate-severe pain in cases such as joint pain, muscle pain, toothache, and severe injuries.

It consists of two ingredients: paracetamol and tramadol. Paracetamol (non-narcotic analgesic) reduces pain and fever, while tramadol (narcotic analgesic) directly acts on the nervous system to block pain signals. Combined, both provide a quick but strong pain-relieving effect for a long duration.

Dulocent 325 mg/37.5 mg Tablet contains a narcotic medicine, so it should be taken strictly as your doctor advises. Take them as a whole, do not crush or chew the tablet. Follow the correct dosage as per the prescription, and do not compensate for missed doses.

Side effects of Dulocent 325 mg/37.5 mg Tablet are usually minor and should not be of any concern. You may experience dry mouth, sleepiness, nausea, vomiting, weakness and dizziness. If they persist for long, contact your doctor.

This medicine is contraindicated (unsafe) for people taking antidepressants such as SSRIs, MAO inhibitors and tricyclic antidepressants. Always let your doctor know of any allergies you might have to the main ingredients and any pre-existing health conditions.

Dulocent 325 mg/37.5 mg Tablet is a combination medicine consisting of paracetamol & tramadol, and it is used to treat moderate to severe pain and provide short-term relief. Apart from pain, it can reduce mild swelling and inflammation in the joints.

This opioid painkiller, coupled with a non-narcotic analgesic, is often prescribed to people with rheumatoid arthritis, osteoarthritis, and injuries. It is also used in post-surgical cases when the patient is in moderate pain.

Since Dulocent 325 mg/37.5 mg Tablet contains tramadol (a strong painkiller), it is often prescribed for long-term pain if any weaker painkillers no longer suffice.

Dulocent 325 mg/37.5 mg Tablet alleviates pain in patients with joint disorders like osteoarthritis and allows them to carry on with their daily life without their joints constantly aching. But in cases like this, doctors prescribe the medication in lower doses for a specific period since it contains a strong opioid analgesic to avoid the risk of addiction.

There are two major groups of analgesics (pain relieving medications): anti-inflammatory analgesics and narcotic opioids. Anti-inflammatory analgesics, also called NSAIDs, are given for mild pain, and the effect wears off quickly. They also reduce inflammation, as the name suggests. Opioid analgesics are far more potent and are only for moderate to severe pain, even in severe cancer-related pain.

Paracetamol reduces low-grade pain (along with fever and inflammation), while tramadol blocks moderate to severe pain to a certain degree. Combined, both provide a quick but strong pain-relieving effect for a considerable duration.

Paracetamol works by selectively inhibiting Cyclooxygenase-3 isoform in the brain and spinal cord. This reduces the production of prostaglandins (the molecules produced by the body when an injury occurs) in the CNS, resulting in a decrease in the sensation of pain.

Tramadol is a centrally-acting synthetic analgesic and it relieves pain in two ways: first, It binds to the µ-opioid receptors in the nervous system. Second, It inhibits/blocks (weakly) reuptake of norepinephrine and serotonin

Combined, both ingredients in Dulocent 325 mg/37.5 mg Tablet reduce pain in three ways, which is why it's considered an effective pain management medication.

Tramadol and morphine

Opioids act on its opioid receptors to produce effects similar to morphine. In medicine, they are primarily used for pain relief. Tramadol is a weak opioid agonist, which means it is not as strong of a pain-killer as morphine, a major analgesic drug, an opium alkaloid and a potent agonist.

Morphine has additional pharmacologic effects like euphoria and respiratory depression, which makes it a far more dangerous medication than Tramadol.

• Tramadol: a brief overview (medlineplus.gov)
• Opioid Analgesics (ncbi.nlm.nih.gov)
• An overview of tramadol and its usage in pain management and future perspective (https://pubmed.ncbi.nlm.nih.gov/)