Doloroff AP 100 mg/500 mg Tablet

Doloroff AP 100 mg/500 mg Tablet is a combination medicine used to treat pain. It consists of two painkillers: aceclofenac and paracetamol, which reduce inflammation and block pain signals. This medication is usually prescribed for joint disorders (osteoarthritis, rheumatoid arthritis, etc.), ear/dental pain, menstrual cramps, headaches and so on.

Doloroff AP 100 mg/500 mg Tablet should be taken as advised by your doctor. The dosage may be adjusted depending on your pain level. It is best to take them whole after your meal with ample water to avoid stomach discomfort. To prevent adverse effects, take it as per your doctor’s prescription.

Side effects of Doloroff AP 100 mg/500 mg Tablet include stomach discomfort, nausea, vomiting, diarrhoea, heartburn, drowsiness and loss of appetite. They typically last for a short period and should not be of any concern. Contact your doctor if they persist or worsen.

Doloroff AP 100 mg/500 mg Tablet is contraindicated for people with a history of stomach ulcers, liver diseases or allergies to either aceclofenac or paracetamol. Always let your doctor know of any health conditions you might have. Generally, this combination drug is considered safe for most people.

Doloroff AP 100 mg/500 mg Tablet is a combination pain medication used to treat mild-moderate pain. It helps alleviate all kinds of general pain that one might experience, including dental pain, ear pain, headaches and fever. This medication is also prescribed in cases of joint pain and disorders like rheumatoid arthritis, menstrual cramps and osteoarthritis.

It consists of 2 active ingredients: aceclofenac and paracetamol. They act as painkillers, antipyretics (medicines that lower body temperature) and anti-inflammatory drugs by inhibiting pain signals in our nervous system and reducing inflammation in our tissue.

Doloroff AP 100 mg/500 mg Tablet helps people with primary dysmenorrhea (pain in the abdomen in women during periods), musculoskeletal pain (injuries or pulled muscles), fever and arthritis. It alleviates pain and most of the discomfort associated with these conditions and allows people to lead an everyday life and do their daily tasks without the hindrance of pain.

Doloroff AP 100 mg/500 mg Tablet contains two medicines: aceclofenac and paracetamol. They lower pain, swelling, inflammation and fever. Let’s look at what they do individually to understand how they work when combined.

Aceclofenac is a non-steroidal anti-inflammatory (NSAID) medicine. It does three things in our body: it lowers pain, reduces inflammation and stops your temperature from increasing. It targets natural chemicals called cyclo-oxygenase enzymes (COX enzymes). Aceclofenac blocks the effect of these COX enzymes, specifically COX-2, and stops them from producing prostaglandins. Thus the inhibition of cyclooxygenase-2-mediated prostaglandins occurs.

Prostaglandins are chemical substances related to pain. They are made at the site of injury or inflammation. When they are blocked or inhibited by medicines like aceclofenac or paracetamol, the pain sensation is reduced.

Paracetamol, also known as acetaminophen, is a non-narcotic analgesic-antipyretic agent. It means it reduces both pain and fever. It works specifically by targeting cyclooxygenase-3-mediated prostaglandins. When compared to aceclofenac, however, it is a weak anti-inflammatory agent.

Combined, aceclofenac and paracetamol in Doloroff AP 100 mg/500 mg Tablet collectively inhibit both cyclooxygenase-3 mediated prostaglandins and cyclooxygenase-2 mediated prostaglandins to offer a superior pain relieving effect.

1. Why the combination: Paracetamol and Aceclofenac?

Paracetamol is an analgesic, which means it reduces mild to moderate pain effectively in most cases. It is, however, ineffective at reducing inflammation. That is why it is combined with aceclofenac, a potent non-steroidal anti-inflammatory drug that inhibits/blocks COX-2.

Thus this combination is used to relieve pain in patients suffering from injury or arthritis since these cases involve not only pain but also severe inflammation.

2. Why is it better to have aceclofenac instead of diclofenac?

Aceclofenac and diclofenac are NSAIDs and target natural chemicals called cyclo-oxygenase enzymes. They block the effect of these COX enzymes and stop them from producing a substance called prostaglandins. Pain and inflammation in tissue are mediated through prostaglandins in our body, so that is why this medication is effective.

But a common side effect of these medicines is gastric upset. People experience nausea, vomiting, diarrhoea or at least a general sense of stomach discomfort after taking NSAIDs. That is because these drugs target COX enzymes (mainly COX-1) that disrupt the mucosal layer of the stomach. When COX-1 enzymes are inhibited, the prostaglandins, which are responsible for keeping the stomach’s mucosal layer healthy, reduce in quantity.

Aceclofenac is superior to other NSAIDs as it has selectivity for cyclo-oxygenase 2 enzymes and produces far fewer gastric upsets than the other drugs in its class. It also has a high cardiac safety in compromised patients. That is why many pain-relieving combination medicines use aceclofenac instead of diclofenac.

• Nonsteroidal Anti-inflammatory Drugs (ncbi.nlm.nih.gov)
• Aceclofenac: a brief overview (ncbi.nlm.nih.gov)
• Philip Anderson - Handbook of Clinical Drug Data-McGraw-Hill Medical (2001)