Bignac-MR 8 Tablet

Bignac-MR 8 Tablet is used in the treatment of pain due to muscle spasms. This tablet contains aceclofenac (pain reliever) and thiocolchicoside (muscle relaxant) which reduce inflammation and relax muscles. It is often prescribed for muscle cramps, myalgia (muscle pain), arthralgia (joint pain), cervicalgia (neck pain), shoulder pain, back pain, etc.

Bignac-MR 8 Tablet should be taken as advised by your doctor. Swallow the tablet whole with ample water after having your food for the best results. The doses will be adjusted depending on your medical condition and the severity of the pain. To prevent adverse effects, take it precisely as per your doctor’s instructions.

Side effects of Bignac-MR 8 Tablet include drowsiness, loss of appetite, dry mouth, stomach pain, heartburn, nausea, vomiting and weakness. They typically last for a short period and usually go away on their own. Contact your healthcare provider if the problems persist.

This medicine is contraindicated (unsafe) for people with liver/kidney diseases, heart problems and hypersensitivity (allergies) to either aceclofenac or thiocolchicoside. It is important to let your doctor know if you are pregnant since this medicine is not prescribed during the last three months of pregnancy. Generally, this combination drug is considered safe for most people.

Bignac-MR 8 Tablet is used in the treatment of pain due to muscle spasms. This tablet reduces inflammation, lowers pain and relaxes the muscles that cause cramps by abnormally contracting (spasms).

This tablet is often prescribed for the following:

Bignac-MR 8 Tablet contains a muscle relaxant and a pain reliever; this combination works by reducing inflammation, lowering pain and relaxing muscles that cause cramps by abnormally contracting (spasms).

This tablet includes two medicines: aceclofenac and thiocolchicoside. Let us look at how they work individually to understand how to treat conditions together.

Aceclofenac is a selective non-steroidal anti-inflammatory drug (NSAID) and phenylacetic acid derivative. As an NSAID, it reduces pain and inflammation without the harmful side effects of corticosteroids. This medicine works by inhibiting the production of prostaglandins, cytokines and interleukins - substances which induce pain and swelling in the body.

NSAIDs usually work by blocking both COX 1 and COX 2 enzymes. Aceclofenac is better than other NSAIDs since it shows a particular selectivity to COX 2 enzyme. This results in lesser gastrointestinal adverse effects such as ingestion, nausea and vomiting.

Thiocolchicoside is a semi-synthetic form of colchicine derivative. It is primarily a muscle relaxant with analgesic (pain relieving) and antiinflammatory properties. It works by acting on the glycine and GABA receptors in the nervous system that are associated with the regulation of muscles. This medicine affects the centres of the brain that control the contraction and relaxation of smooth muscles in the body.

• Aceclofenac - pharmacodynamic properties (pubmed.ncbi.nlm.nih.gov)
• Aceclofenac (medicines.org.uk)
• Muscle Relaxants for Acute and Chronic Pain (pubmed.ncbi.nlm.nih.gov)