Big PM 250mg/325mg Tablet

Big PM 250mg/325mg Tablet contains mefenamic acid and paracetamol, two pain-relieving medicines. It treats moderate to severe pain and is prescribed to women for dysmenorrhea and menorrhagia. This medication works by preventing the body from producing a chemical called prostaglandin. It treats symptoms like headaches, joint pain, toothache, body pain, menstrual cramps (period pain) and excessive menstrual bleeding.

Big PM 250mg/325mg Tablet should be taken as advised by your doctor; the dose may be adjusted depending on the severity of your pain. It is best to take them whole after your meal with ample water to avoid stomach discomfort. To prevent adverse effects, take it as per your doctor’s prescription.

The common side effects of Big PM 250mg/325mg Tablet include stomach discomfort, nausea, vomiting, diarrhoea, constipation, loss of appetite, bloating and ringing in the ears. They typically last for a short period and should not be of any concern. Contact your doctor if they persist or get worse.

Big PM 250mg/325mg Tablet is contraindicated for people with a history of stomach ulcers, stroke, heart failure, epilepsy, ulcerative colitis and allergies to either mefenamic acid or paracetamol. Always let your doctor know of any health conditions you might have. Generally, this combination drug is considered safe for most people.

Big PM 250mg/325mg Tablet is a combination of two pain relievers usually prescribed to women for menstrual cramps (dysmenorrhea) and excessive bleeding (menorrhagia). It also helps alleviate all kinds of pain that one might experience, including dental pain, ear pain, headaches and fever. This medication is prescribed for joint disorders like rheumatoid arthritis and osteoarthritis as well.

Big PM 250mg/325mg Tablet consists of 2 active ingredients: mefenamic acid and paracetamol. Mefenamic acid is an NSAID (non-steroidal anti-inflammatory drug) that blocks the production of a chemical that produces pain and inflammation. When this is explicitly blocked in the uterus lining, menstrual pain is alleviated. Paracetamol reduces both temperature and pain; however, it does not have strong anti-inflammatory effects like mefenamic acid.

Big PM 250mg/325mg Tablet helps people with joint pain (rheumatoid arthritis and osteoarthritis), musculoskeletal pain (injuries or pulled muscles) and fever. It alleviates pain and most of the discomfort associated with these conditions and allows people to lead an everyday life and do their daily tasks without the hindrance of pain.

This medication works by preventing the body from producing a chemical called prostaglandin. Prostaglandins are responsible for the inflammatory processes which lead to pain and fever. Thus, this medicine treats symptoms like headaches, joint pain, toothache, body pain, menstrual cramps (period pain) and excessive menstrual bleeding.

Big PM 250mg/325mg Tablet includes two active ingredients: mefenamic acid and paracetamol. Let’s look at what they do individually to understand how they work when combined.

Mefenamic acid is a non-steroidal anti-inflammatory (NSAID) medicine. It does three things in our bodies: it lowers pain, reduces inflammation and stops your temperature from increasing.

This medicine targets natural chemicals called cyclo-oxygenase enzymes, or COX enzymes for short. It blocks the effect of these enzymes (COX-1 and COX-2) and stops them from producing a substance called prostaglandins. Thus the inhibition of ‘cyclooxygenase-2-mediated prostaglandins’ occurs.

Prostaglandins are chemical substances related to pain. They are made at the site of injury or inflammation. When they are blocked or inhibited by medicines like mefenamic acid or paracetamol, the pain sensation is reduced.

Mefenamic acid is known to specifically target the synthesis of prostaglandins in the uterus lining, which is why it is prescribed for women with menstrual cramps (period pain) and excessive bleeding during periods.

Paracetamol, also known as acetaminophen, is a non-narcotic analgesic antipyretic agent – which means it reduces both pain and fever. It is believed to work by the activation of serotonergic pathways in the brain. However, compared to mefenamic Acid, it is a weak anti-inflammatory agent.

• Nonsteroidal Anti-inflammatory Drugs (ncbi.nlm.nih.gov)
• Mefenamic Acid (medlineplus.gov)
• Philip Anderson - Handbook of Clinical Drug Data-McGraw-Hill Medical (2001)