Sirolimus

Sirolimus is used for prevention of organ rejection in transplant patients. It works by regulating the body’s immune response following organ transplant. This helps your body to accept the new organ as if it were your own.

Sirolimus is a prescription medicine that must be administered by a doctor or a nurse in a hospital or a clinical setting. You must receive the exact dose of it as per the prescription. An overdose of this medicine may have serious side effects on the body.

The common side effects of this medicine include headache, increased heart rate, high blood pressure, abdominal pain, nausea, diarrhea, constipation, rash, acne, joint pain, increased risk of infections, decreased blood cells, and decreased potassium level in blood. If any of the side effects persist or get worse, consult the doctor immediately. Inform the doctor immediately if you experience any allergic reactions such as rash, shortness of breath, coughing, and swelling.

Before taking this medicine, it is important to consult your doctor if you have any ongoing medication for any underlying disease. Pregnant and breastfeeding women must inform the doctor prior to the initiation of this treatment. During the treatment, your doctor may advise you for some laboratory tests to know the effects of the medicine in the body. If you notice signs of infection, any changes in the appearance or size of a mole, unusual growths or lumps, or unusual tiredness or weakness during the treatment, you must consult the doctor immediately.

• Prevention of organ rejection in transplant patients

Prevention of organ rejection in transplant patients
Sirolimus is used with other medications to prevent organ transplant rejection. Rejection usually happens due to attack by the immune system of the person receiving the transplanted organ on the transplant itself, in people who are receiving any organ transplants, like kidney, liver, heart etc. This medicine reduces the activity of a person's own immune system and prevents any such rejection.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Raparen

• Decreased blood cells (red cells, white cells, and platelets)
• Increased risk of infection
• Nausea
• Protein in urine
• Upset stomach
• Abdominal pain
• Constipation
• Decreased potassium level in blood
• Diarrhea
• Headache
• High blood pressure
• Increased heart rate
• Rash
• Joint pain
• Acne

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Sirolimus is an immunosuppressant. It works by suppressing your body’s immune response following transplant of an organ (eg. liver, kidney, heart). This helps your body to accept the new organ as if it were your own.

• Sirolimus is used with other medications to prevent organ transplant rejection.
• Avoid certain vaccines during treatment as the vaccination may be less effective when taking Sirolimus. Consult your doctor.
• Use effective methods of contraception during the treatment and for 12 weeks after Sirolimus has been stopped.
• Limit the exposure to sunlight by covering your skin with clothing and using sunscreen with a high SPF because of the increased risk for skin cancer, when taking Sirolimus.

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1267-68.

Sirolimus [EMC SmPC]. Bruxelles, Belgium: Pfizer Europe MA EEIG; 2001 [revised 13 Mar. 2011]. [Accessed 30 Jan. 2020] (online) Available from:

Sirolimus [FDA Label]. Philadelphia, PA: Wyeth Pharmaceuticals Inc.; 2011. [Accessed 30 Jan. 2020] (online) Available from:

Sirolimus [Package Leaflet]. Co. Kildare, Ireland: Pfizer Ireland Pharmaceuticals; 2019. [Accessed 30 Jan. 2020] (online) Available from: