S-Adenosyl L-Methoinine Disulfate Tosylate

S-Adenosyl L-Methoinine Disulfate Tosylate is a medicine used for the treatment of liver disease associated with reduced bile formation (intrahepatic cholestasis). It protects the liver cells from toxins and helps the liver to perform its normal functions.

S-Adenosyl L-Methoinine Disulfate Tosylate may be taken with or without food. The dose will depend on the severity of your condition and your body weight. It is best swallowed whole, but you may need to break them to get the correct dose. This medicine needs to be taken regularly to get the most benefit and you may have to take it for several months or longer, so try to get into a routine. Keep using it as prescribed even if your symptoms disappear.

Use of this medicine may cause some common side effects such as headache, dizziness, vomiting, upset stomach, diarrhea, constipation, increased sweating, and insomnia. Not everyone gets side effects. If you are worried about them, or they do not go away, let your doctor know. If you have problems with diarrhea your doctor may reduce the dose or stop the treatment. Drink enough water or fluids to stay hydrated in case of severe diarrhea and constipation.

Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy, or breastfeeding. Using this medicine can reduce or increase the effect of some other medicines so tell your doctor, all other medicines you are taking. Avoid drinking alcohol as it might increase side effects.

• Treatment of Liver disease

Treatment of Liver disease
S-Adenosyl L-Methoinine Disulfate Tosylate protects the liver from damage against harmful chemicals, thereby improving overall health of the liver. This helps the liver to perform its normal functions. To make the medicine more effective and for general health benefits, stop smoking, maintain a healthy weight, and do not drink too much alcohol.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Samorac

• Headache
• Dizziness
• Vomiting
• Upset stomach
• Diarrhea
• Constipation
• Increased sweating
• Insomnia (difficulty in sleeping)

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. S-Adenosyl L-Methoinine Disulfate Tosylate may be taken with or without food, but it is better to take it at a fixed time.

S-Adenosyl L-Methoinine Disulfate Tosylate contains S-Adenosyl L-Methoinine Disulfate Tosylate, also known as SAMe, a nutritional supplement, that can restore Glutathione concentrations in the liver and also improves liver damage. SAMe is also involved in many biochemical reactions in the human body that regulate the growth, death and differentiation of hepatocytes (liver cells). Because liver function is compromised in people suffering from liver disease, supplementation with S-Adenosyl L-Methoinine Disulfate Tosylate is beneficial.

• S-Adenosyl L-Methoinine Disulfate Tosylate is prescribed for the treatment of liver disease.
• Seek immediate medical attention if you have difficulty breathing after taking the drug.
• S-Adenosyl L-Methoinine Disulfate Tosylate may interfere with surgery. Its use should be discontinued at least two weeks prior to surgery.
• Avoid smoking and drinking as it further degrades liver functioning.
• You will be regularly monitored for blood creatinine and blood/urine urea levels while on treatment with S-Adenosyl L-Methoinine Disulfate Tosylate.

Guo T, Chang L, Xiao Y, et al. S-adenosyl-L-methionine for the treatment of chronic liver disease: A systematic review and meta-analysis. PLoS One. 2015;10(3):e0122124. [Accessed 02 Jul. 2021] (online) Available from:

Noureddin M, Sander-Struckmeier S, Mato JM. Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review. World J Hepatol. 2020;12(2):46-63. [Accessed 02 Jul. 2021] (online) Available from: