Rosiglitazone

Introduction To Rosiglitazone

Rosiglitazone is a medicine used to treat type 2 diabetes mellitus in adults. It helps control blood sugar levels in people with diabetes. This helps to prevent serious complications of diabetes like kidney damage and blindness.

Rosiglitazone may be used by itself or along with other medicines. It may be taken with or without food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to how it is working.

Keep taking this medicine, even if you feel well or your blood sugar levels are controlled. If you stop it without consulting your doctor, your blood sugar levels could rise and put you at risk of kidney damage, blindness, nerve problems, and loss of limbs. Remember that it is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor. Your lifestyle plays a big part in controlling diabetes.

The most common side effects of taking this medicine include blurred vision, numbness, and bone fracture. Please consult your doctor if these bother you or persist for a longer duration.

You should not take it if you have type 1 diabetes mellitus, if you have diabetic ketoacidosis (high levels of acid in your blood), or if you have severe kidney or liver disease. Before taking this medicine, tell your doctor if you have ever had heart disease, thyroid disease, or some hormonal conditions. It may not be suitable. Pregnant or breastfeeding women should also consult their doctor before taking it. Your blood sugar levels should be checked regularly and your doctor may also advise blood tests to monitor your blood cell counts and liver function.

Uses of Rosiglitazone

  • Treatment of Type 2 diabetes mellitus

Benefits of Rosiglitazone

Treatment of Type 2 diabetes mellitus
Rosiglitazone improves the body’s response to the hormone insulin, that is responsible for regulating blood glucose (sugar) levels in our body. The insulin helps to lower your blood glucose levels and prevents them from rising after taking meals. You should keep taking it for as long as it is prescribed.
Lowering blood glucose levels is an essential part of managing diabetes. If you can control the level you will reduce the risk of getting any of the serious complications of diabetes such as kidney damage, eye damage, nerve problems, and loss of limbs. Taking this medicine regularly along with proper diet and exercise will help you live a normal, healthy life.

Side effects of Rosiglitazone

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Rosinorm

  • Blurred vision
  • Numbness
  • Bone fracture
  • Respiratory tract infection

How to use Rosiglitazone

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rosiglitazone may be taken with or without food, but it is better to take it at a fixed time.

How Rosiglitazone works

Rosiglitazone is an anti-diabetic medication. It works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels.

Quick tips

  • Rosiglitazone has been withdrawn from the market due to an increased risk of heart attack and heart-related deaths.

Safety Advice

sdsPregnancyCONSULT YOUR DOCTOR

Can I take Rosiglitazone if I’m pregnant?

Rosiglitazone may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

sdsBreastfeedingCONSULT YOUR DOCTOR

Can I take Rosiglitazone if I’m breastfeeding?

Information regarding the use of Rosiglitazone during breastfeeding is not available. Please consult your doctor.

sdsAlcoholUNSAFE

Is drinking alcohol while taking Rosiglitazone safe?

It is unsafe to consume alcohol with Rosiglitazone.

sdsDrivingSAFE

Can I drive after taking Rosiglitazone?

Rosiglitazone does not usually affect your ability to drive.

sdsKidneySAFE IF PRESCRIBED

Can I take Rosiglitazone if I have/had kidney diseases?

Rosiglitazone is safe to use in patients with kidney disease. No dose adjustment of Rosiglitazone is recommended.

sdsLiverCAUTION

Can I take Rosiglitazone if I have/had liver diseases?

Rosiglitazone should be used with caution in patients with liver disease. Dose adjustment of Rosiglitazone may be needed. Please consult your doctor. Inform your doctor if you develop any signs and symptoms of jaundice while taking this medicine.

Frequently Asked Questions

Q. Can Rosiglitazone be used along with glimepiride in diabetes?

Rosiglitazone when added to Glimepiride in patients with diabetes mellitus, has been found to significantly reduce plasma lipid levels and significant improvement in blood glucose control related to a reduction in the insulin resistance.

Q. How to use Rosiglitazone?

Rosiglitazone is an anti-diabetes drug used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. Pioglitazone acts as an insulin sensitizer and decreases the extent of insulin resistance in the body too.

Q. How does Rosiglitazone cause oedema?

Rosiglitazone increases the permeability of fluid in tiny blood vessels called capillaries. This results in easier movement of fluids across the membrane and their consequent accumulation, resulting in oedema (puffiness). Also, Pioglitazone causes increased sodium and water reabsorption from the kidney that contributes to the oedema.

Q. How does Rosiglitazone cause heart failure?

Rosiglitazone can cause fluid retention and edema. Consequently, there is a lot of fluid in the body (fluid overload). As a result, it may precipitate heart failure (which worsens with fluid overload in those at risk).

Q. Can Rosiglitazone be used in depression?

Rosiglitazone, either alone or as add-on therapy to conventional treatments, could clinically benefit patients of major depression according to a study

References

Written By:

Dr Advikka Ridhy

Dr Advikka Ridhy

MBBS

RMO, Aster MIMS

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