Promethazine

Introduction To Promethazine

Promethazine is used to treat nausea and vomiting associated with motion sickness, or maybe before and after any surgery. It is also used in combination with other medicines to treat severe allergic reactions (anaphylaxis).

Promethazine is given as an injection under the supervision of healthcare professionals. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. You must inform your doctor if symptoms do not improve within 7 days of the treatment.

The most common side effects of this medicine include dry mouth, blur vision, headache, and feeling dizzy. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. It makes the skin more sensitive towards sunlight. use sunscreen or wear protective clothing before going out.

Before taking this medicine, let your doctor know if you have glaucoma or have asthma issues, or have high blood pressure. Inform your doctor if you are pregnant, or breastfeeding. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Generally, it is advised to avoid alcohol while on treatment.

Uses of Promethazine

  • Treatment of Severe allergic reactions
  • Treatment of Nausea
  • Treatment of Vomiting
  • Treatment of Allergic conditions
  • Treatment of Motion sickness

Benefits of Promethazine

Treatment of Severe allergic reactions
Promethazine is used to treat many different inflammatory and allergic conditions. It works by lowering your immune system’s response to these conditions and prevents the release of substances in the body that cause inflammation. It helps relieve symptoms such as swelling, pain, itching, and other allergic-type reactions. If you are not sure why you are being given this medicine, ask your doctor.
It is given as an injection by a doctor or nurse and should not be self- administered. Taking this medicine enables you to live your life more freely without worrying so much about things that set off your symptoms. Because this medicine weakens your immune system, you should avoid being near people who are ill or have infections.

Treatment of Nausea
Promethazine blocks the action of chemicals in the body that can make you feel or be sick. It is often used to prevent nausea and vomiting that may be caused due to some medicines or any other medical treatment. This medicine helps you recover more comfortably. The dose will depend on what you are being treated for but always take this medicine as it is prescribed.

Treatment of Allergic conditions
Promethazine is used to treat many different inflammatory and allergic conditions. It works by lowering your immune system’s response to these conditions and prevents the release of substances in the body that cause inflammation. It helps relieve symptoms such as swelling, pain, itching, and other allergic-type reactions. If you are not sure why you are being given this medicine, ask your doctor.

This medicine is given orally (by mouth). You should always take it as it has been prescribed for you. Do not stop taking it without your doctor’s advice. This can cause unpleasant withdrawal symptoms. Because this medicine weakens your immune system, you should avoid being near people who are ill or have infections.

Treatment of Motion sickness
Motion sickness is a condition caused due to motion during travel. You may experience spinning sensation (vertigo), nausea or vomiting as a result of this condition. Promethazine helps treat these symptoms effectively. Take it as prescribed by the doctor to get maximum benefit.

Side effects of Promethazine

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Severe side effects of Proxizen

  • Unusual production of breast milk in women and men

How to use Promethazine

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Promethazine works

Promethazine is an antiallergic medication. When your body is exposed to an allergen (pollen, animal dander, house dust etc.), it produces a chemical called histamine. This causes watery eyes, runny or blocked nose, sneezing, skin rashes, itching etc. Promethazine works by blocking the action of histamine, thereby relieving these symptoms. It also works directly on several areas of the brain to prevent nausea/vomiting and help you feel more relaxed.

Quick tips

  • Promethazine helps treat nausea, vomiting and allergic conditions.
  • Use caution while driving or doing anything that requires concentration as Promethazine can cause dizziness and sleepiness.
  • Do not drink alcohol while taking this medication as it may cause increased sleepiness.
  • It may make your skin more sensitive to sunlight. Avoid exposing your skin to strong sunlight, use a sunscreen lotion or make sure your skin is protected with clothing.
  • Do not take it for longer than 7 days. If your symptoms worsen or do not improve after 7 days, talk to your doctor.
  • Stop taking it at least three days before taking an allergy test as it can affect the test results.

Safety Advice

sdsPregnancyCONSULT YOUR DOCTOR

Can I take Promethazine if I’m pregnant?

Promethazine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

sdsBreastfeedingSAFE IF PRESCRIBED

Can I take Promethazine if I’m breastfeeding?

Promethazine is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. For prolonged use and repeated doses of Promethazine, observe the baby for excessive sleepiness.

sdsAlcoholUNSAFE

Is drinking alcohol while taking Promethazine safe?

Promethazine may cause excessive drowsiness with alcohol.

sdsDrivingUNSAFE

Can I drive after taking Promethazine?

Promethazine may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

sdsKidneySAFE IF PRESCRIBED

Can I take Promethazine if I have/had kidney diseases?

Promethazine is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Promethazine may not be needed in these patients. Please consult your doctor. However, caution is advised in patients with severe kidney disease as it may cause excessive sleepiness in them.

sdsLiverCAUTION

Can I take Promethazine if I have/had liver diseases?

Promethazine should be used with caution in patients with liver disease. Dose adjustment of Promethazine may be needed. Please consult your doctor.

Frequently Asked Questions

Q. Is Promethazine or Promethazine DM syrup a narcotic/opiate/pain killer?

Promethazine is antihistaminic drug and not a narcotic/opiate/pain killer. Patient should follow the advice of doctor regarding its use

Q. Is Promethazine over the counter?

No, it is available with doctor's prescription only

Q. Can I take Promethazine for a hangover/sore throat/ nausea/stomach flu/cramps/toothache/ headache/ cough/pain?

Promethazine is used for treatment of symptoms of allergies, but not used for hangover, sore throat, stomach flu, cramps, toothache, headache and cough. Patient should follow the advice of doctor regarding its use

Q. Can I take Promethazine with Nyquil/ codeine and ibuprofen/ Tylenol/ oxycodone/ Benadryl/ Dayquil/ Zofran/codeine and Nyquil/Xanax?

Yes, but taking other medicines may alter the effects of Promethazine. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required

Q. Does Promethazine or Promethazine DM make you sleepy/ get you high/make you tired?

Promethazine may cause these side effects which are not serious. However, always consult your doctor if you experience any of these side effects.

References

Written By:

Dr Advikka Ridhy

Dr Advikka Ridhy

MBBS

RMO, Aster MIMS

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