Prochlorperazine

Prochlorperazine is used in the treatment of nausea and vomiting caused by various conditions. It is also used to treat vertigo (dizziness) due to ear problems (Meniere’s syndrome). This medicine is also used in mental illnesses such as schizophrenia and short-term anxiety.

Prochlorperazine is given by your doctor or nurse. The dose you are given will depend on your condition and how you respond to the medicine. You should take this medicine until your doctor tells you to stop. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine.

The most common side effect is orthostatic hypotension (sudden lowering of blood pressure on standing). This is temporary and usually resolves with time. Contact your doctor straight away if you are at all concerned about these side effects. It may also cause drowsiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen your sleepiness.

Before taking this medicine you should let your doctor know if you have jaundice (yellowing of the skin or eyes), epilepsy, muscle weakness (myasthenia gravis), an underactive thyroid gland, increased pressure in the eye (glaucoma), enlarged prostate gland, liver, kidney, and heart problems. Pregnant or breastfeeding women should consult their doctor. Inform the doctor if you have ever abused alcohol.

• Treatment of Anxiety
• Treatment of Nausea
• Treatment of Vomiting
• Treatment of Migraine
• Treatment of Vertigo
• Treatment of Short term anxiety

Treatment of Anxiety
Prochlorperazine reduces the symptoms of excessive anxiety and worry. It can also reduce feelings of restlessness, tiredness, difficulty concentrating, and feeling irritable. It will therefore help you go about your daily activities more easily and be more productive. Keep taking this medicine even if you feel well. Stopping it suddenly can cause serious problems. So, do not stop taking it without discussing it with your doctor.

Treatment of Nausea
Prochlorperazine blocks the action of chemicals in the body that can make you feel or be sick. It is often used to prevent nausea and vomiting that may be caused due to some medicines and it is also effective in treating nausea/vomiting after an operation (in adults only). The dose will be decided by your doctor and you must always take this medicine as it is prescribed.

Treatment of Migraine
Prochlorperazine helps treat and prevent migraine headaches. It changes the electrical activity in the brain, blocks chemicals responsible for pain sensation and also blocks signals that cause nausea/vomiting associated with migraines. By preventing and reducing the frequency of migraine headaches, it can help you carry out your daily activities and have a better quality of life.

Treatment of Vertigo
Vertigo means a spinning sensation or dizziness that is triggered due to frequent movement or in people suffering from Meniere’s disease. It can happen due to many reasons but it may also occur without any underlying disease. Prochlorperazine helps treat this sensation effectively. If you feel dizzy while getting up from the bed, sit for a while and then rise slowly to avoid having an accidental fall.

Treatment of Short term anxiety
Prochlorperazine reduces the symptoms of excessive anxiety and worry that are triggered only at the time of stressful conditions that last for a shorter duration. These could be job interviews, exams, stage performances, etc. It can effectively manage feelings of restlessness, tiredness, difficulty concentrating, and feeling irritable. Prochlorperazine will therefore help you go about your daily activities more easily and be more productive.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Nausetil

• Drowsiness
• Orthostatic hypotension (sudden lowering of blood pressure on standing)

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Prochlorperazine is a dopamine antagonist. It has an antipsychotic effect by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood. Dopamine also controls the region in the brain that causes nausea and vomiting. Therefore, Prochlorperazine also shows an antiemetic action.

• Prochlorperazine is used for the prevention and treatment of nausea and vomiting.
• It may also be used to treat dizziness associated with problems of the inner ear such as Meniere’s Syndrome.
• It may cause sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.
• To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
• Avoid consuming alcohol when taking the Prochlorperazine as it may cause excessive drowsiness.
• It makes you more likely to get heatstroke. Avoid heavy exercising and drink plenty of fluids.
• It can cause your skin to be more sensitive to sunlight. Avoid exposure to direct sunlight while having this medicine.

Prochlorperazine. King William Street, London: ADVANZ Pharma; 1992 [revised 23 Aug. 2012]. [Accessed 28 Mar. 2019] (online) Available from:

Drugs.com. Prochlorperazine Pregnancy and Breastfeeding Warnings. [Accessed 28 Mar. 2019] (online) Available from:

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Prochlorperazine. [Updated 2018 Oct 31]. [Accessed 20 Feb. 2020] (online) Available from: