Paclitaxel
Introduction To Paclitaxel
Paclitaxel is an anti-cancer medication used for the treatment of breast cancer, pancreatic cancer and non-small cell lung cancer.
It is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Some common side effects of this medicine include nausea, vomiting, and weakness. It may also cause serious side effects such as swelling of hands, lips, hair loss, and weight gain. To reduce these side effects your doctor may suggest some medication along with it. But, inform your doctor if you notice unexplained bruising or bleeding, sore throat, mouth ulcers, high temperature (fever). This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells and liver function.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Paclitaxel
- Breast cancer
- Non-small cell lung cancer
- Pancreatic cancer
Benefits of Paclitaxel
Breast cancer
Paclitaxel helps to treat breast cancer and it may be used alone or in
combination with other medicines or treatment modalities like chemotherapy. It
relieves the symptoms of breast cancer such as breast lumps, bloody discharge
from nipples or changes in the shape or texture of the breast. Paclitaxel
kills or stops the growth of cancer cells and also prevents the multiplication
of cancer cells. Discuss with your doctor if any of the side effects bother
you.
Non-small cell lung cancer
Non-small cell lung cancer is one of the major kinds of lung cancer and it
affects both smokers as well as non-smokers. Paclitaxel helps treat non-small
cell lung cancer and may be given alone or in combination with other
medicines. It is a potent and very toxic medicine and you should discuss the
risks and benefits with your doctor. You should avoid drinking alcohol while
having this treatment and drink plenty of water to stay hydrated.
Pancreatic cancer
Pancreas are very essential for digestion of whatever you eat and also for
metabolism of blood sugar levels as they produce the body’s natural insulin.
This medicine will help to control pancreatic cancer, and will relieve the
symptoms such as, lack of appetite or unexplained weight loss. Paclitaxel
helps to stop the action of those chemicals that aid in pancreatic cancer
growth and spread. It will help you live a longer and healthier life.
Side effects of Paclitaxel
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Pataxel
- Nausea
- Vomiting
- Weakness
- Low blood platelets
- Rash
- Upper respiratory tract infection
- Urinary tract infection
- Bleeding
- Anemia (low number of red blood cells)
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Hair loss
- Decreased blood pressure
- Peripheral neuropathy (tingling and numbness of feet and hand)
- Diarrhea
- Decreased white blood cell count (neutrophils)
How to use Paclitaxel
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Paclitaxel works
Paclitaxel is an anticancer medication. It works by interfering with the microtubule structures which help the cancer cells to divide and multiply. This slows the growth of cancer cells and eventually kills them.
Quick tips
- Paclitaxel is an anti-cancer medication used for the treatment of breast cancer, pancreatic cancer, and non-small cell lung cancer.
- It is given as an intravenous (IV) injection into your vein, usually over 1 hour and every three weeks.
- Do not take Paclitaxel if you are pregnant or breastfeeding. Use reliable methods of contraception to prevent pregnancy while taking this medicine.
- Your doctor may get regular blood tests done to monitor your blood cells and liver function during treatment with this medicine.
- Inform your doctor if you notice unexplained bruising or bleeding, sore throat, mouth ulcers, high temperature (fever) or other signs of infection.
- Talk to your doctor if you have sudden weight gain or if you have swelling in your arms and legs that doesn't go away.
Safety Advice
PregnancyCONSULT YOUR DOCTOR
Can I take Paclitaxel if I’m pregnant?
Paclitaxel is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
BreastfeedingUNSAFE
Can I take Paclitaxel if I’m breastfeeding?
Paclitaxel is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
AlcoholUNSAFE
Is drinking alcohol while taking Paclitaxel safe?
It is unsafe to consume alcohol with Paclitaxel.
DrivingUNSAFE
Can I drive after taking Paclitaxel?
Paclitaxel may cause side effects which could affect your ability to drive. As there is no reason why you cannot continue driving between courses of Paclitaxel but you should remember that this medicine contains some alcohol and it may be unwise to drive
KidneySAFE IF PRESCRIBED
Can I take Paclitaxel if I have/had kidney diseases?
Paclitaxel is safe to use in patients with kidney disease. No dose adjustment of Paclitaxel is recommended. However, talk to your doctor if you have any underlying kidney disease.
LiverCAUTION
Can I take Paclitaxel if I have/had liver diseases?
Paclitaxel should be used with caution in patients with liver disease. Dose adjustment of Paclitaxel may be needed. Please consult your doctor. Use of Paclitaxel is not recommended in patients with severe liver disease.
Frequently Asked Questions
Q. Is Paclitaxel generic/ taxane/ FDA approved/cytotoxic?
Yes, Paclitaxel is generic/ taxane/ FDA approved/ cytotoxic
Q. Is Paclitaxel a vesicant?
Paclitaxel is usually a vesicant (irritant)
Q. Is Paclitaxel light sensitive/ hydrophobic/ cardiotoxic?
Yes, Paclitaxel is light sensitive/ hydrophobic/ cardiotoxic
Q. Does Paclitaxel cause hair loss?
Yes, Paclitaxel may cause hair loss as a side effect. Please inform your doctor about any side effect while you are on Paclitaxel therapy
Q. What is Paclitaxel derived from?
Paclitaxel is derived from bark of the Pacific yew, Taxus brevifolia.
References
Written By:
Dr Advikka Ridhy
MBBS
RMO, Aster MIMS
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