Nimesulide + Paracetamol
Introduction To Nimesulide + Paracetamol
Nimesulide + Paracetamol is a combination pain medication prescribed to treat mild-moderate pain due to rheumatoid arthritis, menstrual cramps and osteoarthritis. It is also used for dental pain, headaches and fever. It consists of 2 active ingredients: nimesulide and paracetamol. They act as painkillers by decreasing both the pain signals sent to the brain and the chemicals that cause fever and pain.
Nimesulide + Paracetamol should be taken as advised by your doctor. It is best to take them as a whole with your meals with ample water to avoid stomach discomfort. To prevent adverse effects, take it precisely as per your prescription.
Side effects of Nimesulide + Paracetamol include stomach discomfort, drowsiness, loss of appetite, nausea, vomiting and lightheadedness. They typically last for a short period and should not be of any concern.
Nimesulide + Paracetamol is contraindicated for people with a history of gastric ulcers, liver diseases or allergies to nimesulide and paracetamol. Always let your doctor know of any health conditions you might have. Generally, this combination is considered safe for most people.
Uses of Nimesulide + Paracetamol
Nimesulide + Paracetamol is a combination pain medication used to treat mild-moderate pain. You may take it if you have dental pain, ear pain, headaches and fever. It is also prescribed in cases of rheumatoid arthritis, menstrual cramps and osteoarthritis.
It consists of 2 active ingredients: nimesulide and paracetamol. They act as painkillers and antipyretics (medicines that lower body temperature) by inhibiting fever and pain signals in your nervous system.
Nimesulide + Paracetamol helps people with primary dysmenorrhea (pain in the abdomen in women during periods), musculoskeletal pain (injuries or pulled muscles), fever and arthritis.
How Nimesulide + Paracetamol works
Nimesulide + Paracetamol includes two active ingredients:nimesulide and paracetamol. Combined, the two inhibit both cyclooxygenase-mediated prostaglandins to offer a superior pain relieving effect.
Nimesulide is a nonsteroidal anti-inflammatory (NSAID) medicine which lowers pain, inflammation and fever. It targets cyclooxygenase-2-mediated prostaglandins, free radicals, proteolytic enzymes and histamine.
Prostaglandins are chemical substances related to pain. They are made at the site of injury or inflammation. When they are blocked or inhibited by medicines like nimesulide or paracetamol, the sensation of pain is reduced.
Paracetamol, also known as acetaminophen, is a non-narcotic analgesic-antipyretic agent. It reduces both pain and fever by targeting cyclooxygenase-mediated prostaglandins. When compared to nimesulide, it is a weak anti-inflammatory agent.
Dosage
Always take Nimesulide + Paracetamol medicine as prescribed by your doctor. Do not consume more than the prescribed dose. Take this medicine as a whole with ample water. Do not chew or crush. You may take this medicine with your meals to reduce the side effects. You may feel slightly sleepy after taking this medication.
Take any missed medication as soon as you recall if you have missed a dose. If it is time for your next dose, ignore the missed dose and continue with the next one. To compensate for a missed dose, avoid taking twice the amount.
Taking more than the prescribed dose of Nimesulide + Paracetamol over a long period may lead to overdose and Acetaminophen intoxication. It is a serious condition in which too much paracetamol is in your body, leading to hepatotoxicity (acute hepatic necrosis) and rarely renal tubular necrosis.
If you experience signs like a change in the urine colour or severe abdominal pain, you may contact your doctor or visit the nearest hospital.
Safety Advice
Nimesulide + Paracetamol is contraindicated if you have kidney problems, liver diseases, stomach ulcers/bleeding, or an allergy to nimesulide or paracetamol. It is not recommended to take Nimesulide + Paracetamol with sedatives and sleeping pills.
Nimesulide + Paracetamol should not be used long-term due to the risk of severe liver damage. Caution is advised while taking this medicine if you have any kidney problems.
PregnancyConsult doctor
Can I take Nimesulide + Paracetamol if I’m pregnant?
BreastfeedingConsult doctor
Can I take Nimesulide + Paracetamol if I’m breastfeeding?
AlcoholUnsafe
Is drinking alcohol while taking Nimesulide + Paracetamol safe?
DrivingUnsafe
Can I drive after taking Nimesulide + Paracetamol ?
Drug interactions
Drug-Food interaction
Consumption of alcohol is not recommended while taking Nimesulide + Paracetamol because it may cause excessive drowsiness or stomach bleeding.
Drug-Disease interaction
Nimesulide + Paracetamol might be contraindicated (unsafe) for people with bleeding disorders, including haemophilia and low blood platelets. Children should not take it if they are suffering from flu or chickenpox. It should also be avoided in case of the presence of gastric or duodenal ulcers.
Drug-Drug interaction
Nimesulide, in Nimesulide + Paracetamol , interacts with corticosteroids (cortisone, prednisone), anti-coagulants (heparin or warfarin), diuretics (spironolactone, furosemide), angiotensin conversion enzyme inhibitors (enalapril, lisinopril).
Drug-Drug Interactions Checker List:
Cortisone Prednisone Heparin warfarin spironolactone Furosemide Enalapril Lisinopril
Frequently Asked Questions
Q. What is Nimesulide + Paracetamol ’s content?
Nimesulide + Paracetamol includes two ingredients: nimesulide and paracetamol. They work to reduce pain, inflammation and fever by inhibiting COX 2 and COX 3, respectively.
Q. Can I use Nimesulide + Paracetamol for headaches?
Yes, Nimesulide + Paracetamol can be used to relieve headache. It contains nimesulide and paracetamol, two painkillers that can alleviate all kinds of general pain.
Q. What is the use of Nimesulide + Paracetamol ?
Nimesulide + Paracetamol is a combination pain medicine prescribed to treat headaches, ear pain, dental pain, joint pain, menstrual cramps and pain due to inflammations.
Q. Should I take Nimesulide + Paracetamol before food or after?
Nimesulide + Paracetamol may be taken with food to reduce the side effects. Take them as a whole and drink plenty of water. Contact your doctor for the correct dose and duration.
Q: What are the side effects of Nimesulide + Paracetamol ?
Nimesulide + Paracetamol ’s side effects include: nausea, vomiting, diarrhoea and stomach discomfort. Seek medical attention if you see signs like yellow skin or pale stools.
References
- Nonsteroidal Anti-inflammatory Drugs (ncbi.nlm.nih.gov)
- Nimesulide: a brief overview (ncbi.nlm.nih.gov)
- Philip Anderson - Handbook of Clinical Drug Data-McGraw-Hill Medical (2001)
Written By:
Dr Advikka Ridhy
MBBS
RMO, Aster MIMS
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