Fludarabine

Introduction To Fludarabine

Fludarabine is used in the treatment of blood cancer called chronic lymphocytic leukemia (CLL). It may be used to treat other conditions, as determined by the doctor. It is sometimes used with certain other medicines as part of combination chemotherapy.

Fludarabine is given as infusion into veins under the supervision of doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include nausea, vomiting, diarrhea, headache, weakness, fever, and cough. This medicine may reduce the number of blood cells (decrease white blood cells and red blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Fludarabine

  • Blood cancer (Chronic lymphocytic leukemia)

Benefits of Fludarabine

Blood cancer (Chronic lymphocytic leukemia)
Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Fludarabine kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective medicine but you should discuss the side effects and benefits of this medicine with your doctor. Let your doctor know if any of the side effects bothers you.

Side effects of Fludarabine

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Fludacel

  • Increased risk of infection
  • Vomiting
  • Weakness
  • Nausea
  • Fatigue
  • Fever
  • Decreased blood cells (red cells, white cells, and platelets)
  • Diarrhea
  • Cough

How to use Fludarabine

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Fludarabine works

Fludarabine is an anticancer medication. It works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells in blood. This slows the growth of cancer cells and eventually kills them.

Quick tips

  • Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
  • Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.

Safety Advice

sdsPregnancyCONSULT YOUR DOCTOR

Can I take Fludarabine if I’m pregnant?

Fludarabine is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

sdsBreastfeedingUNSAFE

Can I take Fludarabine if I’m breastfeeding?

Fludarabine is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

sdsAlcoholCONSULT YOUR DOCTOR

Is drinking alcohol while taking Fludarabine safe?

It is not known whether it is safe to consume alcohol with Fludarabine. Please consult your doctor.

sdsDrivingUNSAFE

Can I drive after taking Fludarabine?

Fludarabine may cause side effects which could affect your ability to drive. Some people get tired, feel weak, have disturbed vision, become confused, or agitated or have seizures while they are treated with Fludarabine and this may affect your ability to drive.

sdsKidneyCAUTION

Can I take Fludarabine if I have/had kidney diseases?

Fludarabine should be used with caution in patients with kidney disease. Dose adjustment of Fludarabine may be needed. Please consult your doctor. Use of Fludarabine is not recommended in patients with severe kidney disease.

sdsLiverCAUTION

Can I take Fludarabine if I have/had liver diseases?

Fludarabine should be used with caution in patients with liver disease. Dose adjustment of Fludarabine may be needed. Please consult your doctor.

References

Written By:

Dr Advikka Ridhy

Dr Advikka Ridhy

MBBS

RMO, Aster MIMS

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