Esomeprazole

Esomeprazole is a medicine that reduces the amount of acid produced in your stomach. It is used for treating acid-related diseases of the stomach and intestine such as acid reflux, peptic ulcer disease, and some other stomach conditions associated with excessive acid production.

Esomeprazole is also used to prevent stress ulcers in seriously ill patients and is administered before anesthetic medication to help prevent aspiration- related complications. It belongs to a class of medicines known as proton pump inhibitors (PPIs). This medicine is administered into a vein by a healthcare professional and will only be given to you if your doctor thinks that an injection is more suitable for you at the moment than a tablet. The dose will depend on your underlying condition and how you respond to the medicine. Additionally, your doctor will decide the duration of treatment. You can increase the efficiency of the treatment by eating smaller meals more often and avoiding caffeinated drinks (like tea and coffee), and spicy or fatty foods.

The most common side effects observed with this medicine include nausea, headache, dizziness, flatulence, diarrhea, stomach pain, and injection site reactions. These symptoms are generally mild but if they bother you or do not go away, consult your doctor. Talk to your doctor about ways to prevent bone loss (osteoporosis), like taking calcium and vitamin D supplements.

Esomeprazole is not suitable for some people. Before taking this medicine, you need to tell your doctor if you have severe liver problems, are taking medicines for HIV, have ever had an allergic reaction to similar medicines in the past, or suffer from bone loss (osteoporosis). Pregnant or breastfeeding women should also consult their doctor before taking it. Avoid drinking alcohol as it makes your stomach produce excessive acid and can worsen your symptoms.

• Treatment of Gastroesophageal reflux disease (Acid reflux)
• Treatment of Peptic ulcer disease

Treatment of Gastroesophageal reflux disease (Acid reflux)
GERD is a chronic (long-term) condition that is like having heartburn consistently rather than just occasionally. It happens because a muscle above your stomach relaxes too much and allows stomach contents to come back up into your esophagus and mouth. Esomeprazole belongs to a group of medicines called proton pump inhibitors. It reduces the amount of acid your stomach makes and relieves the pain associated with heartburn and acid reflux. You should take it exactly as it is prescribed for it to be effective.

Some simple lifestyle changes can help reduce the symptoms of GERD. Think about what foods trigger heartburn and try to avoid them; eat smaller more frequent meals; try to lose weight if you are overweight and try to find ways to relax. Do not eat within 3-4 hours of going to bed.

Treatment of Peptic ulcer disease
Esomeprazole belongs to a group of medicines called proton pump inhibitors. It reduces the amount of acid your stomach makes which prevents further damage to the ulcer as it heals naturally. You may be given other medicines along with this medicine depending on what caused the ulcer. You need to keep taking the medicine as it is prescribed for it to be effective, even if the symptoms seem to disappear.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Esoser

• Injection site reaction
• Headache
• Dizziness
• Dryness in mouth
• Nausea
• Abdominal pain
• Constipation
• Flatulence
• Diarrhea

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Esomeprazole is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in relief of acid related indigestion and heartburn.

• It is given as an injection into a vein under the supervision of the doctor.

• It is a well-tolerated medicine and provides relief for a long time.

• Some healthy tips to prevent acidity from happening:

  • Avoid excessive intake of carbonated beverages/soft drinks, citrus juices, fried food, caffeinated beverages like tea and coffee.
  • Avoid alcohol and smoking.
  • Avoid eating late at night or before bedtime.

• Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away.

• Long-term use of Esomeprazole can cause weak bones and a deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor.

• Consult your doctor right away if you develop decreased urination, edema (swelling due to fluid retention), lower back pain, nausea, fatigue, and rash or fever. These could be signs of a kidney problem.

Wallace JL, Sharkey KA. Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: The McGraw-Hill Companies, Inc.; 2011. [Accessed 24 Jan. 2019] (online) Available from:

Esomeprazole sodium [FDA Label]. Wilmington, DE: AstraZeneca LP; 2012. [Accessed 24 Apr. 2020] (online) Available from:

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Esomeprazole. [Updated 2019 Jun 3]. [Accessed 20 Feb. 2020] (online) Available from:

Central Drugs Standard Control Organisation (CDSCO). [Accessed 28 Mar. 2019] (online) Available from: