Domperidone + Paracetamol

Domperidone + Paracetamol is used to relieve migraine headaches and to treat nausea and vomiting associated with it. This medicine may also be used in ailments where fever is accompanied by vomiting.

Give $ to your child orally, preferably 30 minutes before meals. Stick to the dose, time, and way prescribed by your doctor as that depends on your child's clinical condition, body weight, and age. In case your child vomits within 30 minutes of taking this medicine, let the child calm down, and then repeat the dose.

Domperidone + Paracetamol should be given at the first sign of a migraine attack. If symptoms persist, further doses may be given but a gap of 4 hours must be maintained between each dose. However, never exceed the total dose that has been prescribed for a day.

Diarrhea, rash, restlessness, and drowsiness are some of the common yet temporary side effects of this medicine. Make sure to report to your child's doctor if the side effects persist or become bothersome for your child.

Before giving this medicine to your child, let the doctor know if your child has had any previous episodes of medicine allergy, metabolic disorder, liver impairment, kidney malfunction, asthma, or blood disorder. This information is critical for dose alterations and for planning your child's overall treatment.

• Treatment of Migraine

Treatment of Migraine
Domperidone + Paracetamol is a combination of medicines that helps prevent migraine by changing the way that your nerves receive pain signals. It also blocks the action of chemicals in the body that can make you feel or be sick. This treats as well as prevents nausea or vomiting effectively. By preventing and reducing the frequency of headaches, it can help you carry out your daily activities and have a better quality of life.

Domperidone + Paracetamol does not pose serious side effects and is well-tolerated by children. In case the side effects do occur, they’re likely to subside once the body adapts to the medicine. Consult your child’s doctor if these side effects persist or bother your child. The most common side effects include-

Common side effects of Domcet

• Diarrhea
• Rash
• Restlessness
• Drowsiness

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Domperidone + Paracetamol is to be taken empty stomach.

Domperidone + Paracetamol contains two medicines: Domperidone and Paracetamol. Domperidone is an antiemetic that works on the vomiting center in the brain. It also increases the movement of the muscles of the stomach and intestines, allowing food to move more easily through the stomach. This prevents nausea and vomiting caused due to migraines. Paracetamol is an analgesic (pain reliever) and an antipyretic (fever reducer) which blocks the release of certain chemical messengers that cause the pain associated with migraine.

• If diarrhea develops as a side effect, encourage your child to drink plenty of fluids.

• Never give any other medicines containing paracetamol along with this medicine as that may lead to serious side effects.

• Do not alter the dose by yourself as it can result in unwanted side effects in your child.

• Do not mix Domperidone + Paracetamol with any herbal or ayurvedic preparations as it will not be effective.

• Stop the medicine and report to the doctor on an immediate basis if your child exhibits side effects such as itching, breathing difficulty, and swelling of the face soon after taking Domperidone + Paracetamol.

• Domperidone + Paracetamol helps to ease the pain you feel during a migraine headache as well as helps to stop you from feeling sick.

• Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.

• Inform your doctor if you are taking any pain relief medicine.

• Domperidone + Paracetamol can only decrease the number and severity of attacks but may not completely stop them.

• Some tips that may help avoid a migraine attack:

  1. Have your meals at the same time every day.
  2. Avoid bright lights and extreme temperatures.
  3. Avoid loud music and noisy places.
  4. Avoid chocolates, cheese, processed food, alcohol, and smoking.
  5. Get sufficient sleep and avoid stress.

Royal United Hospitals Bath: NHS. Using Domperidone + Ibuprofen/Aspirin/Paracetamol for Migraine Attacks. 2017. [Accessed 22 Feb. 2021] (online) Available from:

MacGregor EA, Wilkinson M, Bancroft K. Domperidone plus paracetamol in the treatment of migraine. Cephalalgia. 1993;13(2):124-7. [Accessed 22 Feb. 2021] (online) Available from:

Ong JJY, De Felice M. Migraine Treatment: Current Acute Medications and Their Potential Mechanisms of Action. Neurotherapeutics 2018;15:274-90. [Accessed 22 Feb. 2021] (online) Available from: