Domperidone + Flunarizine + Paracetamol

Domperidone + Flunarizine + Paracetamol is a prescription medicine used in the treatment of migraine. It prevents pain signals and fever associated with migraine. It also blocks certain substances in the brain that trigger nausea or vomiting during migraine headaches.

Domperidone + Flunarizine + Paracetamol is taken without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine.

The most common side effects are weight gain, and dryness in the mouth. These are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. It may also cause drowsiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen your drowsiness.

Migraine attacks can be managed by identifying migraine-causing triggers which may be red wine, caffeine withdrawal, stress, and skipped meals, etc. You can identify personal triggers by maintaining a diary of what you are doing, what you are eating, and any stressful activity happened before migraine attack. Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding. You should also tell your doctor if you have any liver diseases.

• Migraine

Migraine
Domperidone + Flunarizine + Paracetamol is a combination of medicines that treat and prevent migraine headaches. It changes the electrical activity in the brain, blocks chemicals responsible for pain sensation and also blocks signals that cause nausea/vomiting associated with migraines. By preventing and reducing the frequency of migraine headaches, it can help you carry out your daily activities and have a better quality of life.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Bio Migron

• Weight gain
• Drowsiness
• Dryness in mouth

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Domperidone + Flunarizine + Paracetamol is to be taken empty stomach.

Domperidone + Flunarizine + Paracetamol is a combination of three medicines: Domperidone, Flunarizine and Paracetamol which prevent migraine accompanied by nausea/vomiting. Domperidone is an antiemetic and prokinetic which blocks the action of a dopamine (a chemical messenger) in the brain which causes nausea and vomiting. Flunarizine is a calcium channel blocker which works by preventing the narrowing of blood vessels in the head thereby preventing migraine headache. Paracetamol is an analgesic (pain reliever) and antipyretic (fever reducer). It blocks the release of certain chemical messengers in the brain that are responsible for pain.

• Domperidone + Flunarizine + Paracetamol helps to ease the pain you feel during a migraine headache as well as helps to stop you from feeling sick.

• It can make you feel dizzy, rise slowly if you have been sitting or lying down for a long time.

• Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.

• Domperidone + Flunarizine + Paracetamol can only decrease the number and severity of attacks but may not completely stop them.

• Some tips that may help avoid a migraine attack:

  1. Have your meals at the same time every day.
  2. Avoid bright lights and extreme temperatures.
  3. Avoid loud music and noisy places.
  4. Avoid chocolates, cheese, processed food, alcohol, and smoking.
  5. f) Get sufficient sleep and avoid stress.

Domperidone maleate. South Ruislip, Middlesex: Aurobindo Pharma - Milpharm Ltd.; 2017. [Accessed 15 Feb. 2019] (online) Available from:

Sibelium. Ringaskiddy, Ireland: Janssen Sciences Ireland UC; 2019. [Accessed 15 Feb. 2019] (online) Available from:

NHS. Paracetamol for adults. [Accessed 15 Feb. 2019] (online) Available from:

ScienceDirect. Flunarizine. [Accessed 12 Apr. 2019] (online) Available from: