Disulfiram

Introduction To Disulfiram

Disulfiram is a medicine used in the treatment of alcohol addiction. It works by producing interaction with alcohol and thereby causing unpleasant effects like nausea, flushing of the face, headaches. Thus, it discourages the patient from taking alcohol while on this medication.

Disulfiram may be taken with or without food. Take this medicine as advised by your doctor and if you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course of treatment. This medication mustn't be stopped suddenly without talking to your doctor. Remember while taking this medication, avoid alcohol in all forms including beer, wine, aftershave lotions, mouthwash, vinegar, and liquid medications.

Some common side effects of using this medication are headache, fatigue, drowsiness, and metallic taste. Initially, it may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. It is important to know that you should take this medicine in combination with a counseling program as it will provide extra help to maintain abstinence from alcohol. Remember it will take time, support, willpower, and determination to readjust the habit of not drinking.

Uses of Disulfiram

  • Treatment of Alcohol addiction

Benefits of Disulfiram

Treatment of Alcohol addiction
Disulfiram is a medicine used, along with social support and counseling, to help people recover from alcohol addiction and to avoid having the urge to drink alcohol again. It causes sudden, undesirable effects when mixed with alcohol to help you refrain from alcohol, even if you are dependent on alcohol. It causes effects such as flushing of the face, headache, nausea, blurred vision, mental confusion etc., when even small amounts of alcohol are consumed.

Disulfiram starts working from the very first dose and is a very safe and effective way of treating alcohol addiction. Avoid taking foods containing alcohol like mouthwash, cough medicines, perfumes or deodorants, and even hair dyes as even small amounts of alcohol can trigger these unpleasant effects.

Side effects of Disulfiram

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Cronotol

  • Headache
  • Fatigue
  • Drowsiness
  • Metallic taste

How to use Disulfiram

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Disulfiram may be taken with or without food, but it is better to take it at a fixed time.

How Disulfiram works

Disulfiram blocks the chemical which breaks the converted form of alcohol in the body. This leads to an increased level of converted form of alcohol in the body causing bad physical features while drinking alcohol.

Quick tips

  • Disulfiram is used together with behavior modification, psychotherapy, and counseling support to help you stop drinking.
  • It works best for patients who can achieve initial abstinence of at least 12 hours, are committed to maintaining abstinence, and agree to take the medication.
  • While taking this medication, avoid alcohol in all forms including beer, wine, aftershave lotions, mouthwash, vinegar, certain desserts, colognes, and liquid medications.
  • When you first start taking it, you may feel dizzy, confused, tired, and weak. Don't drive or do anything that requires mental focus until you know how it affects you.
  • You may notice an aftertaste of either garlic or metal when you start taking Disulfiram. Inform your doctor if this does not go away.
  • Inform your doctor if you have a history of heart disease, liver or kidney disease, psychiatric problems, diabetes, or if you're allergic to latex rubber or pesticides.
  • Do not take it if you are pregnant, planning a pregnancy, or breastfeeding.

Safety Advice

sdsPregnancyCONSULT YOUR DOCTOR

Can I take Disulfiram if I’m pregnant?

Disulfiram may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

sdsBreastfeedingCONSULT YOUR DOCTOR

Can I take Disulfiram if I’m breastfeeding?

Disulfiram is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

sdsAlcoholUNSAFE

Is drinking alcohol while taking Disulfiram safe?

It is unsafe to consume alcohol with Disulfiram.

sdsDrivingUNSAFE

Can I drive after taking Disulfiram?

Disulfiram may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

sdsKidneyCAUTION

Can I take Disulfiram if I have/had kidney diseases?

Disulfiram should be used with caution in patients with kidney disease. Dose adjustment of Disulfiram may be needed. Please consult your doctor.

sdsLiverCAUTION

Can I take Disulfiram if I have/had liver diseases?

Disulfiram should be used with caution in patients with liver disease. Dose adjustment of Disulfiram may be needed. Please consult your doctor.

Frequently Asked Questions

Q. Is Disulfiram safe/dangerous?

Yes, Disulfiram is safe if used at prescribed doses for the prescribed duration in a hospital or specialized clinic as advised by your special doctor

Q. Is Disulfiram over-the-counter medicine?

No, Disulfiram is not an over-the-counter medicine. Disulfiram treatment for alcohol withdrawal should be initiated only in a hospital or specialized clinic and by experienced doctors only. Patients should follow advice of the doctor regarding its use

Q. Is Disulfiram addictive?

No, Disulfiram is not addictive. It is used to treat alcohol addiction and chronic alcoholism

Q. Does Disulfiram work?

Yes, Disulfiram works. Disulfiram is an aldehyde dehydrogenase inhibitor. It works by blocking the processing of alcohol in the body causing unpleasant feeling leading to alcohol withdrawal

Q. Does Disulfiram work for everyone?

Disulfiram works for chronic alcoholics who are cooperative and willing to give up alcoholism. Patients should follow advice of the doctor regarding its use

Q. Does Disulfiram stops cravings?

Disulfiram blocks the processing of alcohol in the body causing unpleasant feeling due to these unpleasant episodes, alcoholics abstain from alcohol Therefore, patients may avoid consuming alcohol to avoid unpleasant reactions upon consuming alcohol even days after stopping Disulfiram. It may not have any direct effects on cravings

Q. Does Disulfiram work immediately?

Yes, Disulfiram works on alcohol withdrawal as soon as you start the treatment

References

Written By:

Dr Advikka Ridhy

Dr Advikka Ridhy

MBBS

RMO, Aster MIMS

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