Dextromethorphan Hydrobromide + Paracetamol + Phenylephrine

Dextromethorphan Hydrobromide + Paracetamol + Phenylephrine contains three active medicines which together effectively treat symptoms such as dry cough (cough with no mucus), runny nose, fever, sneezing, itching, and watery eyes. These symptoms are usually caused by the common cold and other respiratory conditions in children.

Give Dextromethorphan Hydrobromide + Paracetamol + Phenylephrine to your child orally in the dose, time, and way prescribed by your child's doctor. You can give this medicine with or without food, but giving it with food will help prevent the chances of stomach upset. The dose of Dextromethorphan Hydrobromide + Paracetamol + Phenylephrine will depend on your child's clinical condition, body weight, and age. Prefer giving this medicine at a fixed time to prevent the chance of missed dose. If your child vomits within 30 minutes of the intake, give the same dose again. Your child may start to feel better within a few days of regular dosing. However, you must finish the prescribed course as stopping it abruptly may worsen your child's condition.

Your child may exhibit minor and transient side effects like vomiting, diarrhea, nausea, dizziness, rash, and headache after the intake of Dextromethorphan Hydrobromide + Paracetamol + Phenylephrine. Usually, these episodes subside once your child's body adapts to the medicine. However, in case of prolonged or bothersome events, better consult your child's doctor without any delay.

Narrate your child's complete medical history to the doctor. Do let the doctor know if your child is on a medicine regime or has had any history of allergies, heart problems, blood disorders, birth defects, airway obstruction, lung anomaly, skin disorders, liver impairment, and kidney malfunction. This information is critical for dose alterations and for planning your child's overall treatment.

• Treatment of Dry cough

Treatment of Dry cough
A dry cough is a cough where no phlegm or mucus is produced. It may cause a tickling sensation or itching in the throat. Dextromethorphan Hydrobromide + Paracetamol + Phenylephrine suppresses severe dry cough and gives your child relief from an itchy throat. Along with taking this medicine, gargling with warm salt water and having ginger or honey can help your child manage the dry cough.

Dextromethorphan Hydrobromide + Paracetamol + Phenylephrine does not pose serious side effects and is well-tolerated by children. In case the side effects do occur, they’re likely to subside once the body adapts to the medicine. Consult your child’s doctor if these side effects persist or bother your child. The most common side effects include-

Common side effects of Xtro

• Vomiting
• Nausea
• Diarrhea
• Dryness
• Drowsiness
• Headache
• Skin rash

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Dextromethorphan Hydrobromide + Paracetamol + Phenylephrine may be taken with or without food, but it is better to take it at a fixed time.

Dextromethorphan Hydrobromide + Paracetamol + Phenylephrine is a combination of three medicines: Dextromethorphan Hydrobromide, Phenylephrine, and Paracetamol which relieve dry cough. Dextromethorphan Hydrobromide is a cough suppressant that relieves cough by reducing the activity of the cough center in the brain. Phenylephrine is a decongestant that narrows the small blood vessels providing relief from congestion or stuffiness in the nose. Paracetamol is an analgesic (pain reliever) and antipyretic (fever reducer). It works by blocking the production of chemical messengers (prostaglandins) that transmit pain signals and induce fever.

• Never self-medicate at home. Always consult your child’s doctor before giving any medicine to your child.

• Dextromethorphan Hydrobromide + Paracetamol + Phenylephrine may make your child feel sleepy. Ensure your child takes extra care when taking part in physical activities.

• Never combine Dextromethorphan Hydrobromide + Paracetamol + Phenylephrine with other cold and flu medicines as that may lead to side effects.

• Stop Dextromethorphan Hydrobromide + Paracetamol + Phenylephrine and immediately report to the doctor if your child develops an itchy rash, facial swelling, or breathing difficulties.

• Practice self-care tips:

  1. Clean and disinfect surfaces after sneezing and coughing to avoid allergy.
  2. Give your child plenty of fluids as it helps to thin and loosen the mucus accumulated in the lungs.
  3. Restrain your child from having caffeinated products and foods that are spicy and fried. All these can trigger coughing.
  4. Make your child gargle with warm saltwater.
  5. Ensure your child takes enough rest.

Drugs.com. Chlorpheniramine, dextromethorphan, and phenylephrine. [Accessed 25 Jun. 2021] (online) Available from:

Acetaminophen [FDA Label]. Lake Zurich, IL: Fresenius Kabi USA, LLC.; 2015. [Accessed 25 Jun. 2021] (online) Available from:

Barnes PJ. Pulmonary Pharmacology. In: Brunton LL, Hilal-Dandan R, Knollmann BC (Editors). Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 13th ed. New York, New York: McGraw-Hill Medical; 2018. p. 743.

National Health Service. Paracetamol for children (including Calpol). [Last reviewed 16 Jul. 2019]. [Accessed 25 Jun. 2021] (online) Available from: