Clomiphene

Clomiphene is a medicine used to treat female infertility. It is used in women who are unable to become pregnant, due to ovulation problems or suffering from polycystic ovary syndrome (PCOS).

Clomiphene should be taken with or without food, but take it at the same time every day to get the most benefit. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. It is not a safe medicine for long term use, hence it is usually advisable for a period of 3 menstrual cycles.

The most common side effects of this medicine include nausea, vomiting, bloating, headache, and hot flushes. If these bother you or appear serious, let your doctor know. Some serious side effects which mean your doctor should know immediately include ovary overstimulation (pelvic pain, stomach pain, trouble breathing and weight gain), and blurring of vision.

Before taking this medicine, tell your doctor if you have ever had an early menopause or infertile, or have ovarian fibroids or swollen ovary. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Generally, you should avoid alcohol while taking this medicine.

• Female infertility

Female infertility
Clomiphene helps in normal development of an egg in a woman's ovary (female reproductive organ), and stimulates the release of a healthy, matured egg. This helps to treat infertility in women and increases the chance of a successful pregnancy. It is commonly used in women who are taking treatment for ovulation related issues or for polycystic ovary syndrome (PCOS). Take this medicine in the dose and duration prescribed by the doctor.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Ubiphene C

• Nausea
• Vomiting
• Bloating
• Headache
• Enlarged ovary
• Hot flashes
• Metrorrhagia (menstrual bleeding at irregular intervals)
• Breast discomfort

Take this medicine in the dose and duration as advised by your doctor. Clomiphene may be taken with or without food, but it is better to take it at a fixed time.

Clomiphene is a selective estrogen receptor modulator (SERM) which treats female infertility. It works by promoting the release of reproductive hormones. This helps stimulate the release of eggs from the ovary (ovulation).

• Clomiphene promotes the release of reproductive hormones so it is used in women who cannot get pregnant because they are not ovulating or have a condition called polycystic ovary syndrome.

• It is not safe for long-term use. Hence, it is advisable not to use it for more than 3 menstrual cycles.

• The medicine will cause ovulation after 5-10 days. It is advisable to have regular intercourse during this period.

• It may cause blurring of vision. Be cautious while driving or doing anything requiring mental focus.

• Inform your doctor if you experience abdominal pain and distention, nausea, vomiting, diarrhea, and weight gain while taking this medicine.

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Chrousos GP. The Gonadal Hormones & Inhibitors. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 718-19.

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 296-98.

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