Ciprofloxacin + Tinidazole

Ciprofloxacin + Tinidazole treats bacterial and parasitic infections in various body parts, including the genitals, gastrointestinal tract, urinary tract, etc. It consists of two antimicrobial drugs: ciprofloxacin and tinidazole. This medication is usually prescribed for dysentery, amebiasis, giardiasis, trichomoniasis and other microbial infections.

Ciprofloxacin + Tinidazole should be taken as advised by your doctor. It is best to take them whole after your meal with plenty of fluids to avoid stomach discomfort. To prevent adverse effects, take it as per your doctor’s prescription. Do not discontinue taking this medicine even if you feel better.

Side effects of Ciprofloxacin + Tinidazole include nausea, vomiting, headache, stomach pain, tiredness and dry mouth with a metallic taste. They typically last for a short period and should not be of any concern. Contact your doctor if they persist or worsen.

Ciprofloxacin + Tinidazole is contraindicated for people with a history of liver diseases, renal failure, nerve disorders, and allergies to either ciprofloxacin or tinidazole. Always let your doctor know of any health conditions you might have. Generally, this combination drug is considered safe for most people.

Ciprofloxacin + Tinidazole is used to treat bacterial and parasitic infections in the genitals, gastrointestinal tract, urinary tract, lung infections, etc. This medication is generally prescribed for dysentery, amebiasis, giardiasis, trichomoniasis and other microbial infections.

Ciprofloxacin + Tinidazole consists of two ingredients: ciprofloxacin and tinidazole. They act as antimicrobial drugs and kill/halt the growth of infective agents such as protozoa, parasites and anaerobic bacteria.

Ciprofloxacin + Tinidazole combines two antimicrobial drugs: ciprofloxacin (an antibiotic) and tinidazole (an antiprotozoal). When administered together, they kill the infection-causing bacteria and protozoan parasites.

Ciprofloxacin Is a II generation fluoroquinolone, a bactericidal antibiotic. It works as a broad-spectrum drug (effective against a wide range of bacteria) and kills both gram-positive and gram-negative bacteria.

The way ciprofloxacin works is by preventing the bacterial cells from multiplying. It functions by blocking/inhibiting certain enzymes within the cell, such as DNA gyrase, type II topoisomerase, and topoisomerase IV enzymes. These enzymes are necessary for separating bacterial DNA, which is crucial for cell division.

Tinidazole is a nitroimidazole antimicrobial. It works against both parasites (protozoans) and anaerobic bacteria. The mechanism of action involves the activation of this drug by the enzymes the microbes produce; upon activation, certain toxic compounds are formed, which are harmful to the cells of these microbes. This results in the damage of proteins, membranes and the DNA found inside the cell.

Tinidazole is used to treat trichomoniasis (an STD caused by Trichomonas vaginalis), giardiasis (a diarrheal disease caused by Giardia duodenalis), and amebiasis (an intestinal infection caused by Entamoeba histolytica) - all protozoal infections.

1. Cartilage damage, tendonitis and tendon rupture

Ciprofloxacin is generally avoided (contraindicated) for pregnant women and children under 15 years because it might cause damage to growing cartilage. Ciprofloxacin is known to cause some level of cartilage damage, tendonitis (inflammation of the thick cords that attach muscle to bone) and tendon rupture. Some studies show potential for arthropathy as well.

Due to these side effects, ciprofloxacin has been used in children 6–16 yr old and pregnant women in limited situations to treat serious infections.

2. CNS side effects.

Ciprofloxacin is lipophilic (tending to combine with or dissolve in fats); thus it has the ability to cross a border called the blood–brain barrier and enter the CNS (central nervous system). This is why in rare cases, patients who take ciprofloxacin for a long duration experience problems associated with the nervous system, like mental fog, agitations, insomnia and seizures.

3. Do not go out into the sun.

People who take ciprofloxacin occasionally develop photosensitive skin; that is, they become more sensitive to sunlight than they are normally. Exposure to sunlight, in these situations, may cause sunburn, discolouration, skin rash, and itching.

After you take ciprofloxacin you should avoid exposing your eyes and skin to sunlight (and other sources of artificial UV light) for at least 24 hours.

• Tinidazole (ncbi.nlm.nih.gov)