Ciprofloxacin + Tinidazole

Introduction To Ciprofloxacin + Tinidazole

Ciprofloxacin + Tinidazole treats bacterial and parasitic infections in various body parts, including the genitals, gastrointestinal tract, urinary tract, etc. It consists of two antimicrobial drugs: ciprofloxacin and tinidazole. This medication is usually prescribed for dysentery, amebiasis, giardiasis, trichomoniasis and other microbial infections.

Ciprofloxacin + Tinidazole should be taken as advised by your doctor. It is best to take them whole after your meal with plenty of fluids to avoid stomach discomfort. To prevent adverse effects, take it as per your doctor’s prescription. Do not discontinue taking this medicine even if you feel better.

Side effects of Ciprofloxacin + Tinidazole include nausea, vomiting, headache, stomach pain, tiredness and dry mouth with a metallic taste. They typically last for a short period and should not be of any concern. Contact your doctor if they persist or worsen.

Ciprofloxacin + Tinidazole is contraindicated for people with a history of liver diseases, renal failure, nerve disorders, and allergies to either ciprofloxacin or tinidazole. Always let your doctor know of any health conditions you might have. Generally, this combination drug is considered safe for most people.

Uses of Ciprofloxacin + Tinidazole

Ciprofloxacin + Tinidazole is used to treat bacterial and parasitic infections in the genitals, gastrointestinal tract, urinary tract, lung infections, etc. This medication is generally prescribed for dysentery, amebiasis, giardiasis, trichomoniasis and other microbial infections.

Ciprofloxacin + Tinidazole consists of two ingredients: ciprofloxacin and tinidazole. They act as antimicrobial drugs and kill/halt the growth of infective agents such as protozoa, parasites and anaerobic bacteria.

How Ciprofloxacin + Tinidazole works

Ciprofloxacin + Tinidazole combines two antimicrobial drugs: ciprofloxacin (an antibiotic) and tinidazole (an antiprotozoal). When administered together, they kill the infection-causing bacteria and protozoan parasites.

Ciprofloxacin Is a II generation fluoroquinolone, a bactericidal antibiotic. It works as a broad-spectrum drug (effective against a wide range of bacteria) and kills both gram-positive and gram-negative bacteria.

The way ciprofloxacin works is by preventing the bacterial cells from multiplying. It functions by blocking/inhibiting certain enzymes within the cell, such as DNA gyrase, type II topoisomerase, and topoisomerase IV enzymes. These enzymes are necessary for separating bacterial DNA, which is crucial for cell division.

Tinidazole is a nitroimidazole antimicrobial. It works against both parasites (protozoans) and anaerobic bacteria. The mechanism of action involves the activation of this drug by the enzymes the microbes produce; upon activation, certain toxic compounds are formed, which are harmful to the cells of these microbes. This results in the damage of proteins, membranes and the DNA found inside the cell.

Tinidazole is used to treat trichomoniasis (an STD caused by Trichomonas vaginalis), giardiasis (a diarrheal disease caused by Giardia duodenalis), and amebiasis (an intestinal infection caused by Entamoeba histolytica) - all protozoal infections.

Dosage

Ciprofloxacin + Tinidazole should be taken as prescribed by your doctor. Do not stop the use of this medicine even if you feel better. Take it as a whole with ample water; do not chew or crush. You may take it after food to reduce the chances of stomach upset.

If you forget to take this medicine, take it as soon as you remember. If it is time for your next dose, ignore the one that you missed and continue with the next. Do not take twice the amount to compensate for a missed dose.

If you experience allergic or overdose symptoms like itchy skin, swollen face or difficulty breathing, seek medical attention immediately.

Safety Advice

Ciprofloxacin + Tinidazole is not recommended for people with severe liver/kidney diseases, colitis, nerve-related problems and allergy to either ciprofloxacin or tinidazole. Always let your doctor know of any health conditions you might have. After taking Tinidazole, one of the ingredients in Ciprofloxacin + Tinidazole , it is recommended to wait at least 14 days before taking a Cholera vaccine.

sdsPregnancyCaution

Can I take Ciprofloxacin + Tinidazole if I’m pregnant?

sdsBreastfeedingCaution

Can I take Ciprofloxacin + Tinidazole if I’m breastfeeding?

sdsAlcoholUnsafe

Is drinking alcohol while taking Ciprofloxacin + Tinidazole safe?

sdsDrivingUnsafe

Can I drive after taking Ciprofloxacin + Tinidazole ?

Drug interactions

Drug-Food interaction

Consumption of alcohol is not recommended while taking Ciprofloxacin + Tinidazole because it may cause severe adverse effects. Avoid consuming dairy products within 2 hours of taking this medication. It is best to avoid caffeine products as well.

Drug-Disease interaction

Ciprofloxacin + Tinidazole may not be given to people with central nervous system disorders to avoid adverse effects like tremors, anxiety, restlessness and hallucinations. This medication is contraindicated for people with colitis (inflammatory disease of the colon), neurological disorders and severe kidney and liver diseases.

Drug-Drug interaction

Please consult your doctor if you are currently taking the following medicines: cardiac glycoside (digoxin), blood thinners (warfarin), immunosuppressant (cyclosporine), antiepileptics (phenobarbital, phenytoin), antihyperlipidemic drugs (atorvastatin), phosphodiesterase inhibiting drugs (theophylline) and medicines to treat chronic alcoholism (disulfiram).

Drug-Drug Interactions Checker List:

Digoxin Warfarin Cyclosporine Phenobarbital Phenytoin Atorvastatin Disulfiram Theophylline

Frequently Asked Questions

Q. What is Ciprofloxacin + Tinidazole ’s content?

Ciprofloxacin + Tinidazole consists of ciprofloxacin, an antibiotic; and tinidazole, an antiprotozoal agent. They treat various infections by killing the disease-causing protozoa and bacteria.

Q. What is Ciprofloxacin + Tinidazole used for?

Ciprofloxacin + Tinidazole is an antimicrobial medicine that treats parasitic and bacterial infections in various body parts, including the genitals, gastrointestinal tract, urinary tract, etc.

Q. What are the side effects of Ciprofloxacin + Tinidazole ?

Side effects of Ciprofloxacin + Tinidazole include nausea, tiredness, dry mouth with a metallic taste and a mild headache. Contact your doctors if they worsen.

Q. Should I take Ciprofloxacin + Tinidazole before food or after?

Ciprofloxacin + Tinidazole can be taken with or without food. To reduce its adverse effects, take them after food, and avoid dairy products and caffeinated drinks.

Q. Can I stop taking Ciprofloxacin + Tinidazole when my symptoms are relieved?

Ciprofloxacin + Tinidazole contains antibiotic medicines; thus, this therapy should not be stopped when you feel better. Complete the course as per your doctor’s instruction.

Learn more

  1. Cartilage damage, tendonitis and tendon rupture

Ciprofloxacin is generally avoided (contraindicated) for pregnant women and children under 15 years because it might cause damage to growing cartilage. Ciprofloxacin is known to cause some level of cartilage damage, tendonitis (inflammation of the thick cords that attach muscle to bone) and tendon rupture. Some studies show potential for arthropathy as well.

Due to these side effects, ciprofloxacin has been used in children 6–16 yr old and pregnant women in limited situations to treat serious infections.

  1. CNS side effects.

Ciprofloxacin is lipophilic (tending to combine with or dissolve in fats); thus it has the ability to cross a border called the blood–brain barrier and enter the CNS (central nervous system). This is why in rare cases, patients who take ciprofloxacin for a long duration experience problems associated with the nervous system, like mental fog, agitations, insomnia and seizures.

  1. Do not go out into the sun.

People who take ciprofloxacin occasionally develop photosensitive skin; that is, they become more sensitive to sunlight than they are normally. Exposure to sunlight, in these situations, may cause sunburn, discolouration, skin rash, and itching.

After you take ciprofloxacin you should avoid exposing your eyes and skin to sunlight (and other sources of artificial UV light) for at least 24 hours.

References

Written By:

Dr Advikka Ridhy

Dr Advikka Ridhy

MBBS

RMO, Aster MIMS

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