Acitretin

Introduction To Acitretin

Acitretin is a medicine that is similar to vitamin A and is involved in the normal growth of skin cells. It is used in the treatment of psoriasis. It works by stopping the overgrowth and thickening of skin cells.

Acitretin is taken with food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine.

The most common side effects are dry lips, dryness in the mouth, skin peeling, joint pain, itching, runny nose, nosebleeds, hair loss, and increased levels of blood fat. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. It may cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can make dizziness worse.

Avoid sun exposure and cover the treated areas with clothing or use a sunscreen before stepping out in the sun. Your doctor may get your regular blood tests done to monitor your liver function and the levels of fats such as cholesterol in your blood. You should tell your doctor if you have any kidney or liver diseases so that your doctor can prescribe a suitable dose for you. Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding as Acitretin can cause fetal abnormalities.

Uses of Acitretin

  • Psoriasis

Benefits of Acitretin

Psoriasis
Psoriasis is a condition where the skin cells in the body grow too quickly and form scales and dry patches. They can grow anywhere, but most appear on the scalp, elbows, knees, and lower back. Acitretin reduces the scaly, itchy patches along with other symptoms of inflammation such as redness, swelling or irritation which may develop on the different parts of the body. It also stops the overgrowth and thickening of the skin. Take it for as long as it is prescribed to get the most benefit. It may take several months to become fully effective. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side effects of Acitretin

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Sentrane

  • Dryness in mouth
  • Skin peeling
  • Itching
  • Hair loss
  • Dry skin
  • Lip inflammation
  • Dry eye
  • Inflammation of the nose

How to use Acitretin

Take this medicine in the dose and duration as advised by your doctor. Acitretin is to be taken with food.

How Acitretin works

Acitretin is a retinoid. It has a structure similar to vitamin A and is involved in the normal growth of skin cells. It works by stopping overgrowth and thickening of skin cells in psoriasis.

Quick tips

  • Acitretin helps reduce thickening, plaque formation and scaling of the skin in conditions such as psoriasis.
  • Take it at the same time every day with food or a glass of milk.
  • Do not take Acitretin if you are pregnant, planning pregnancy or breastfeeding as it can cause birth defects in babies. Use effective methods of contraception to prevent pregnancy.
  • You will need to take pregnancy tests regularly if you are on treatment with and for at least 3 years after you stop taking this medicine.
  • Avoid exposure to sunlight while using Acitretin as it increases the sensitivity of your skin. Use protective measures such as sun-creams and protective clothing.
  • It may cause dryness of skin, mouth, and lips. Drink plenty of water and use a moisturiser and lip balm, if needed.
  • It may cause dry eyes and blurring of vision. Avoid wearing contact lenses and be cautious before driving or using machines.
  • Your doctor may get your regular blood tests done to monitor your liver function and the levels of fats such as cholesterol in your blood.

Safety Advice

sdsPregnancyUNSAFE

Can I take Acitretin if I’m pregnant?

Acitretin is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

sdsBreastfeedingCONSULT YOUR DOCTOR

Can I take Acitretin if I’m breastfeeding?

Acitretin is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

sdsAlcoholUNSAFE

Is drinking alcohol while taking Acitretin safe?

It is unsafe to consume alcohol with Acitretin.

sdsDrivingUNSAFE

Can I drive after taking Acitretin?

Acitretin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

sdsKidneyCAUTION

Can I take Acitretin if I have/had kidney diseases?

Acitretin should be used with caution in patients with kidney disease. Dose adjustment of Acitretin may be needed. Please consult your doctor.

sdsLiverCAUTION

Can I take Acitretin if I have/had liver diseases?

Acitretin should be used with caution in patients with liver disease. Dose adjustment of Acitretin may be needed. Please consult your doctor.

Frequently Asked Questions

Q. Is Acitretin an immunosuppressant?

No, Acitretin is not an immunosuppressant. It belongs to the retinoid class of medicines. It is used to treat severe form of psoriasis.

Q. Can I drink alcohol while taking Acitretin?

Do not consume anything that contains alcohol while taking Acitretin and for 2 months after treatment. Acitretin and alcohol combine to form a substance that may remain in the body for more than 3 years.

Q. How long does Acitretin take to work?

Acitretin does not work right away. It may take about 2-4 weeks to see an improvement and about 2-3 months before you see the full benefits of this medicine. Therefore, you should continue taking it even if you do not see any improvement initially.

Q. What is the most important information that I should know about Acitretin?

Acitretin can cause serious birth defects in your unborn child. Therefore, you should not take Acitretin if you are pregnant or plan to become pregnant within the next 3 years. Acitretin may also cause liver damage. Therefore, contact your doctor immediately if you experience nausea, vomiting, loss of appetite, pain in the upper right part of the stomach, yellowing of the skin or eyes, or dark urine.

Q. Does Acitretin affect sperm?

No, Acitretin does not affect the sperm. However, it has been seen that small amounts of this medicine may pass into the semen. But, this small amount does not pose a risk to an unborn child.

Q. How should I take Acitretin?

It is generally recommended to take Acitretin once daily with meals or milk. The dosage varies from person to person and is decided by your doctor. Swallow the medicine whole and do not crush or cut it.

Q. Can I donate blood while on Acitretin?

No, you should not donate blood while on Acitretin. Moreover, do not donate blood 3 years after stopping the treatment with Acitretin. The medicine present in your blood can harm an unborn child if your blood is given to a pregnant mother. However, Acitretin does not affect your ability to receive a blood transfusion.

Q. What should I avoid while taking Acitretin?

Acitretin may affect your night vision. Therefore, you should avoid driving at night. Avoid supplemental foods containing vitamin A while taking this medicine since it may add to the side effects. Also, avoid sunlight and sun lamps as Acitretin can make your skin more sensitive to ultraviolet light.

References

Written By:

Dr Advikka Ridhy

Dr Advikka Ridhy

MBBS

RMO, Aster MIMS

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